PMID: 8969937Nov 1, 1996Paper

Sex differences in the human metabolism of cortisol

Endocrine Research
P W Raven, N F Taylor

Abstract

Sex differences in steroid metabolism have been clearly demonstrated in animal studies, but few studies have addressed this question in the human. Our preliminary studies suggested human sex differences in both cortisol production and metabolism. We therefore looked in more detail at indices of cortisol metabolism derived from 24 hour urinary steroid profiles in a group of 20 men and 20 women who were age-matched, drug-free and had no endocrine disorder. Steroid analysis was by high resolution gas chromatography. Men excreted more total cortisol metabolites (7620 +/- 620 v 4750 +/- 380 micrograms/24 h, p < 0.001), 11-oxo metabolites of cortisol (11-oxo FM, 4320 +/- 400 v 2890 +/- 250 micrograms/24 h, p < 0.001) and 11 beta-hydroxy metabolites of cortisol (11-OH FM, 3290 +/- 240 v 1860 +/- 140 micrograms/24 h, p < 0.001). These differences remained significant when corrected for body surface area. The ratio of 11-oxo FM/11-OH FM, an index of 11 beta-hydroxysteroid dehydrogenase (11-HSD) activity, was higher in women (1.57 +/- 0.07 v 1.31 +/- 0.06, p < 0.01). The ratios of 5 alpha/5 beta and 20-oxo/20-OH metabolites of cortisol were both higher in men (1.07 +/- 0.15 v 0.58 +/- 0.04, p < 0.01, and 2.78 +/- 0.06 v 2.27 +/- 0.11, p ...Continue Reading

References

Aug 1, 1980·The Journal of Clinical Endocrinology and Metabolism·B V Zumoff, H L Bradlow
Sep 1, 1994·Annals of Clinical Biochemistry·E J LambJ M Burrin
Mar 1, 1996·Annals of Clinical Biochemistry·N Taylor, P Raven

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Citations

Mar 7, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J R KatzS W Coppack
Jul 20, 2007·American Journal of Physiology. Endocrinology and Metabolism·Stefan A WudyThomas Remer
Aug 26, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P F SvendsenS B Pedersen
Jun 19, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniel M KeenanJohannes D Veldhuis
Aug 22, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Thomas RemerStefan A Wudy
Jul 27, 2006·Psychosomatic Medicine·Walid K JerjesAnthony J Cleare
Jan 26, 2006·Endocrine Reviews·Vanessa E MurphyVicki L Clifton
Apr 4, 2002·Experimental Aging Research·Nelson Carvalhaes-NetoClaudio E Kater
Apr 18, 2003·Endocrine Reviews·Anthony J Cleare
Jul 8, 2020·International Journal of Environmental Research and Public Health·Petra Maria GaumJessica Lang
Jul 15, 2015·Endocrine·Francesca Pecori Giraldi, Alberto G Ambrogio
Dec 1, 2003·Acta Neuropsychiatrica·A J Cleare
Aug 5, 2017·Frontiers in Endocrinology·Claudia BoettcherStefan A Wudy
Oct 8, 2020·American Journal of Physical Anthropology·Leslie QuadeRebecca Gowland
May 1, 2021·Journal of Clinical Medicine·André FarkouhAlexandra Kautzky-Willer
Jan 28, 2006·Journal of Psychosomatic Research·Walid K JerjesAnthony J Cleare

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