Sex differences in the long-term prognostic value of 13 N-ammonia myocardial perfusion positron emission tomography

European Journal of Nuclear Medicine and Molecular Imaging
Catherine GebhardPhilipp A Kaufmann

Abstract

Evidence to date on the unique female determinants of cardiovascular risk is inadequate. Positron Emission Tomography (PET) is considered to have the highest accuracy for the assessment of myocardial perfusion in patients with suspected coronary artery disease (CAD), but its long-term prognostic accuracy in women has not been established. A total of 619 consecutive patients (138 women, mean age 60.0 ± 11.8 years) underwent clinically indicated 13N-ammonia PET at our institution and were followed up (median 5.7 years) for major adverse cardiovascular events (MACE) including cardiac death, nonfatal myocardial infarction, hospitalization for any cardiac reason and late revascularization. During follow-up, 271 patients had at least one cardiac event, including 64 cardiac deaths and 33 nonfatal myocardial infarctions. In both women and men, abnormal myocardial perfusion was associated with reduced event-free survival (log rank p < 0.001). In women, abnormal myocardial perfusion was associated with a higher risk of a worse outcome than in men (adjusted HR 4.1, 95% CI 1.8-9.0 in women; HR 2.4, 95% CI 1.5-3.8 in men; pinteraction < 0.001). In contrast, abnormal coronary flow reserve (CFR) was a significant predictor of 10-year MACE in ...Continue Reading

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Citations

Oct 1, 2019·Journal of the American Heart Association·Michael FiechterCatherine Gebhard
Jan 17, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Ahmed HaiderCatherine Gebhard
Jul 31, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Dominik C BenzRonny R Buechel
Jun 30, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Caroline E GebhardCatherine Gebhard
Dec 26, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Roberta GreenAlberto Cuocolo
Jun 9, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Monika MaredziakCatherine Gebhard
Jan 14, 2022·European Journal of Nuclear Medicine and Molecular Imaging·Ahmed HaiderCatherine Gebhard

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