Sex differences in the metabolic effects of diet-induced obesity vary by age of onset

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Abigail E SalineroKristen L Zuloaga

Abstract

Sex differences in the effect of diet-induced obesity (DIO) have been reported in juvenile mice. However, thorough side by side comparisons of the effects of DIO in males and females at different ages of onset have yet to be examined. We hypothesized that aged females would lose their protection, relative to males, from the effects of DIO. We examined the effect of DIO on body weight and glucose tolerance in juvenile, young adult, and middle-aged male and female mice. Our data show DIO in juvenile mice causes a greater increase in body weight and greater impairment in glucose tolerance in males than females. However, if the diet is initiated in young adult mice, these sex differences are absent. Further, if the diet is initiated in middle-aged mice, the sex difference is reversed, and females gain more weight and have greater impairment in glucose tolerance than males. Our data show that sex differences in the effect of DIO vary by age of onset; thus highlighting the importance of both age and sex as biological variables in DIO research.

References

Jul 9, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T KellyJ He
Feb 17, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K L GroveD J Clegg
Aug 21, 2013·Diabetes & Metabolic Syndrome·June TesterLydia Tinajero-Deck
Jun 3, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R S DakinA J Drake
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kristen L ZuloagaNabil J Alkayed

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Citations

Sep 18, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Abigail E SalineroKristen L Zuloaga
Jul 24, 2020·The Journal of Clinical Investigation·Jenny C LinkKaren Reue
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Barbara C SorkinGuido F Pauli
Jul 2, 2020·Biology of Sex Differences·Charly Abi-GhanemKristen L Zuloaga
May 19, 2018·Frontiers in Physiology·Ryan ToedebuschLakshmi Pulakat
Sep 27, 2020·Molecular Nutrition & Food Research·Bianca F LeonardiAline R Zimmer
Dec 3, 2020·Nutrients·Nicole L Stott, Joseph S Marino
Mar 20, 2021·Diabetology & Metabolic Syndrome·Mariana de Moura E DiasFermín Ignacio Milagro
May 7, 2021·Journal of Cellular and Molecular Medicine·Haiyan PangJianzhong Sheng
Oct 21, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gina N CalcoZhenying Nie

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