Sex differences in the modulation of K+ currents in diabetic rat cardiac myocytes

The Journal of Physiology
Yakhin Shimoni, Xiu-Fang Liu

Abstract

A transient (Ipeak) and a sustained (Isus) outward K+ current were measured, using whole-cell voltage-clamp methods, in isolated rat ventricular myocytes obtained by enzymatic dispersion. A comparison was made between male and female rats following induction of (insulin-deficient) diabetes with streptozotocin (STZ). In control (non-diabetic) rats, both currents were smaller in cells obtained from females, as compared to males (P<0.005). However, whereas inducing diabetes in male rats significantly attenuated both Ipeak and Isus (P<0.005), Ipeak was unchanged in female diabetic rats. Isus was significantly (P<0.005) reduced, but the extent of reduction was smaller (P<0.02) than in males. The formation of angiotensin II (ATII) or endothelin-1 (ET-1) was blocked using inhibitors of angiotensin-converting enzyme (ACE) and endothelin-converting enzyme (ECE), respectively. In cells from diabetic males both inhibitors significantly (P<0.005) enhanced K+ currents. In contrast, no effect was observed in cells from female diabetic rats. However, in ovariectomized (Ovx) diabetic females the in vitro inhibition of ATII and ET-1 formation augmented the two K+ currents, but not when oestradiol was administered in vivo prior to cell isolation...Continue Reading

References

Dec 1, 1993·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·J BachmannD Ganten
Sep 23, 1997·Journal of Cardiovascular Electrophysiology·B Surawicz
Jan 22, 1998·The American Journal of Physiology·K B BrosnihanC M Ferrario
May 23, 1998·The Biochemical Journal·A K MoreyE R Levin
Jun 6, 1998·Cardiovascular Research·M Näbauer, S Kääb
Jul 8, 1998·Journal of Cardiovascular Electrophysiology·J A Larsen, A H Kadish
Feb 4, 1999·Hypertension·P E GallagherK B Brosnihan
Aug 6, 1999·Cardiovascular Research·M L Kuroski de Bold
Aug 10, 1999·Diabetes/metabolism Research and Reviews·S H WildS Comte
Apr 26, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·F FiordalisoJ Kajstura
Sep 6, 2000·Trends in Pharmacological Sciences·F D Russell, P Molenaar
Dec 29, 2000·Journal of the American College of Cardiology·H M ColhounJ H Fuller
Jul 24, 2001·American Journal of Hypertension·S VermaJ H McNeill
Sep 5, 2001·Circulation Research·V Trépanier-BoulayC Fiset
Sep 19, 2001·Circulation·M van EickelsP A Doevendans
Feb 28, 2002·Cardiovascular Research·Jeanine E Roeters van LennepErnst E van der Wall
Feb 28, 2002·Cardiovascular Research·Jacques E Rossouw
Feb 28, 2002·Cardiovascular Research·Marcus FischerHeribert Schunkert
Feb 28, 2002·Cardiovascular Research·Fawzi A BabikerPieter A Doevendans
Feb 28, 2002·Cardiovascular Research·Thai V Pham, Michael R Rosen
Feb 28, 2002·Cardiovascular Research·Yuejin Wu, Mark E Anderson
Jun 11, 2002·Biochemical and Biophysical Research Communications·Agnieszka Lachowicz, Elzbieta Rebas
Jul 2, 2002·JAMA : the Journal of the American Medical Association·Deborah GradyUNKNOWN HERS Research Group
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Judy R FreshourKaren L Vikstrom
Mar 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Yakhin Shimoni, Xiu-Fang Liu

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Citations

Aug 22, 2007·Biological Trace Element Research·Murat AyazIlhami Demirel
Mar 17, 2006·Diabetologia·M L SchwankeA J Davidoff
Jun 28, 2005·Progress in Biophysics and Molecular Biology·Andrew F JamesJules C Hancox
Dec 25, 2003·The Journal of Physiology·Yakhin ShimoniDavid L Severson
Jul 22, 2009·Journal of Molecular and Cellular Cardiology·Noriko Niwa, Jeanne M Nerbonne
Jan 24, 2007·Journal of the American College of Cardiology·Andrew J SauerLi Zhang
Jun 4, 2013·Computers in Biology and Medicine·Jerzy CieniawaJustyna Widomska
Apr 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Yakhin Shimoni, Xiu-Fang Liu
May 10, 2005·Journal of Cardiovascular Electrophysiology·Arash Arya
Jul 6, 2005·British Journal of Pharmacology·Yakhin Shimoni
Dec 13, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Yakhin ShimoniGary Kargacin
Mar 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Yakhin ShimoniGary Kargacin
Sep 25, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Nazmi YarasBelma Turan
May 9, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Ihab DorottaRichard Applegate
May 9, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Gary R Stier, Edward W Verde
Nov 4, 2016·Physiological Reviews·Vera Regitz-Zagrosek, Georgios Kararigas

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