Sex differences in the myocardial inflammatory response to ischemia-reperfusion injury

American Journal of Physiology. Endocrinology and Metabolism
Meijing WangDaniel R Meldrum

Abstract

The myocardium generates inflammatory mediators during ischemia-reperfusion (I/R), and these mediators contribute to cardiac functional depression and apoptosis. The great majority of these data have been derived from male animals and humans. Sex has a profound effect over many inflammatory responses; however, it is unknown whether sex affects the cardiac inflammatory response to acute myocardial I/R. We hypothesized the existence of inherent sex differences in myocardial function, expression of inflammatory cytokines, and activation of the p38 mitogen-activated protein kinase (MAPK) signaling pathway after I/R. Isolated rat hearts from age-matched adult males and females were perfused (Langendorff), and myocardial contractile function was continuously recorded. After I/R, myocardium was assessed for expression of TNF-alpha, IL-1beta, and IL-6 (RT-PCR, ELISA); IL-1alpha and IL-10 mRNA (RT-PCR); and activation of p38 MAPK (Western blot). All indexes of postischemic myocardial function [left ventricular developed pressure, left ventricular end-diastolic pressure, and maximal positive (+dP/dt) and negative (-dP/dt) values of the first derivative of pressure] were significantly improved in females compared with males. Compared with...Continue Reading

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Citations

Aug 9, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Chunyan HuangMeijing Wang
Jun 8, 2010·American Journal of Physiology. Heart and Circulatory Physiology·M A Hassan TalukderJay L Zweier
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