Sex Differences in the Neural Correlates of Spatial Context Memory Decline in Healthy Aging

Journal of Cognitive Neuroscience
S. SubramaniapillaiM Natasha Rajah

Abstract

Aging is associated with episodic memory decline and alterations in memory-related brain function. However, it remains unclear if age-related memory decline is associated with similar patterns of brain aging in women and men. In the current task fMRI study, we tested the hypothesis that there are sex differences in the effect of age and memory performance on brain activity during episodic encoding and retrieval of face-location associations (spatial context memory). Forty-one women and 41 men between the ages of 21 and 76 years participated in this study. Between-group multivariate partial least squares analysis of the fMRI data was conducted to directly test for sex differences and similarities in age-related and performance-related patterns of brain activity. Our behavioral analysis indicated no significant sex differences in retrieval accuracy on the fMRI tasks. In relation to performance effects, we observed similarities and differences in how retrieval accuracy related to brain activity in women and men. Both sexes activated dorsal and lateral PFC, inferior parietal cortex, and left parahippocampal gyrus at encoding, and this supported subsequent memory performance. However, there were sex differences in retrieval activity...Continue Reading

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Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

Matlab
Caret
SPM8 Toolbox
Prime
Statistical Parametric Mapping
ArtRepair
R
plsgui
R “ lmerTest
lme4

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