Sex Differences in the Neuroadaptations of Reward-related Circuits in Response to Subchronic Variable Stress

Neuroscience
Song ZhangMing-Hu Han

Abstract

Women are twice as likely to be diagnosed with major depressive disorder. However, fewer studies in rodent models of depression have used female animals, leading to a relative lack of understanding of the female brain's response to stress, especially at a neural circuit level. In this study, we utilized a 6-day subchronic variable stress (SCVS) mouse model and measured novelty suppressed feeding as behavioral criteria to evaluate susceptibility to SCVS in male and female mice. First, we showed that SCVS induced a decrease in latency to eat (susceptible phenotype) in female mice, but not in males (resilient phenotype). After determining behavioral phenotypes, we investigated the firing activities of dopamine (DA) neurons in the ventral tegmental area (VTA), as well as the neurons that project from lateral habenula (LHb) to the VTA and from locus coeruleus (LC) to the VTA. Utilizing retrograding lumafluor fluorescent tracers and electrophysiology techniques, we performed cell type- and circuit-specific measures of neuronal firing rates. Our data show that SCVS significantly increased the firing rate of LHb-VTA circuit neurons in female mice when compared to that of their female controls, an effect that was absent in SCVS-exposed ...Continue Reading

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Citations

Jan 29, 2020·Genes, Brain, and Behavior·Elena BrivioAlon Chen
Sep 22, 2020·Brain and Neuroscience Advances·Laurel S MorrisJames W Murrough
Dec 26, 2018·Frontiers in Synaptic Neuroscience·Caroline A BrowneIrwin Lucki
Mar 16, 2021·Tobacco Use Insights·Matthew Bucklin
Apr 6, 2021·The European Journal of Neuroscience·Qun Y LvHong Liao
Apr 19, 2021·Biological Psychiatry·Jennifer R RainvilleGeorgia E Hodes
May 8, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Saba AmiriMehdi M Mirbagheri
May 10, 2021·Biological Psychiatry·Joëlle Lopez, Rosemary C Bagot
Jul 18, 2019·Molecular Neuropsychiatry·Kelly BarkoRyan W Logan

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