Sex Differences in the Neuroimmune System

Current Opinion in Behavioral Sciences
Brittany F OsborneJaclyn M Schwarz

Abstract

While sex differences in the peripheral immune response have been studied extensively, sex differences in the neuroimmune response, including glial activation and associated cytokine production in the brain, is a recently emerging field. Advances in our understanding of sex differences in the neuroimmune response have important implications for understanding how neural circuits are shaped during early brain development, how activation of the immune system may impact cognitive function and behavior, and how inflammation may be associated with the risk of mental health disorders that have strong sex-biases. The goal of this mini review is to highlight recent work in the field of sex differences in neuroimmune function, with a particular focus on how microglia function is influenced by age and sex hormone exposure.

Citations

Jun 5, 2020·Nursing Research·Marliese Dion NistRita H Pickler
Jan 4, 2019·Journal of Molecular Neuroscience : MN·Joanna A RuszkiewiczMichael Aschner
May 11, 2019·International Journal of Molecular Sciences·Maryam ArdalanCarina Mallard
Nov 17, 2020·Frontiers in Behavioral Neuroscience·Vipan K PariharCharles L Limoli
Oct 18, 2020·Molecular and Cellular Neurosciences·Jack Reddaway, Nichola M Brydges
Nov 27, 2020·Frontiers in Neuroscience·Farid YaghoubySrikanth Vasudevan
Mar 9, 2021·Brain Plasticity·Ignatius Alvarez CooperSelena E Bartlett
Mar 19, 2021·Journal of Neuroinflammation·Jinming HanRobert A Harris
Mar 27, 2021·Mechanisms of Ageing and Development·Julie A Chowen, Luis M Garcia-Segura
Jul 13, 2021·Behavioural Brain Research·Alexandra TuranoJaclyn M Schwarz

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