Sex differences in the peripheral and central immune responses following lipopolysaccharide treatment in pubertal and adult CD-1 mice

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Rupali SharmaN Ismail

Abstract

Puberty is a critical developmental period that is characterized by significant brain development. Exposure to stress during this time can alter brain functioning setting the stage for long-lasting behavioural outcomes. The objective of this study was to investigate age and sex differences in the peripheral and central immune responses, along with sickness behaviour, following immune stress. The results showed that LPS treatment increased serum cytokine levels and sickness symptoms in all mice. Pubertal males displayed increased IL-1β concentrations at 2 h and increased IL-6 concentrations at 8 h post-treatment whereas increased concentrations of TNFα, IL-10, IL-12, IL-1β, IFNγ, and IL-6 persisted at 8 and 24 h in adult females. Consistent with peripheral cytokines, pubertal males displayed greater IL-1β, TNFα, and IL-6 mRNA expression in the prefrontal cortex at 2 h, whereas adult males expressed more of the aforementioned cytokines at 8 h compared to saline controls. Adult males also displayed greater IL-1β mRNA expression compared to their female counterparts, and adult females displayed greater TNFα mRNA expression compared to their male counterparts. These results not only provide a better understanding of the age and sex ...Continue Reading

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Citations

Feb 10, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rupali SharmaNafissa Ismail
Jul 25, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Geraldine ZenzPeter Holzer
Jul 22, 2019·Frontiers in Neuroendocrinology·Mariya TsyglakovaGeorgia E Hodes
Nov 10, 2020·Alcoholism, Clinical and Experimental Research·Hui Peng, Kimberly Nixon
Mar 12, 2021·Frontiers in Psychiatry·Caroline J Smith, Staci D Bilbo
Jul 28, 2020·IScience·Faten TakiMiklos Toth
Aug 2, 2021·Brain Research Bulletin·Daria Kolmogorova, Nafissa Ismail

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