Sex differences in the relationship between obesity, C-reactive protein, physical activity, depression, sleep quality and fatigue in older adults

Brain, Behavior, and Immunity
Rudy J ValentineJeffrey A Woods

Abstract

Fatigue is a serious health concern in the elderly. Sex differences exist in adiposity, systemic inflammation, physical activity/fitness and fatigue; however, the relations among these variables remain inadequately characterized impeding the development of fatigue prevention strategies. Measures of adiposity, C-reactive protein, physical activity, aerobic fitness, fatigue, sleep quality and depression were obtained from 127 community-dwelling older adults. Although similar in age (70 y) and BMI (28.0kg/m(2)) women (n=80) reported 63% greater fatigue than men (p=0.04). Adiposity (r=0.44), CRP (r=0.29), physical activity (r=-0.26) and fitness (r=-0.41) were related to fatigue in women (all p<0.05), but not in men. Depression was also related to fatigue in women (r=0.37), and was the only variable related to fatigue in men (r=0.42). In women, fatigue was independently explained (all p<0.05) by CRP (6.6%), depression (6.3%), physical activity (5.8%), and adiposity (3.9%); however, in men, only depression explained variance in fatigue (12.0%). CRP was 40% higher and adiposity 12% higher in women reporting fatigue compared to those with no fatigue; no such differences existed in men. Obese women perceived a greater degree of fatigue ...Continue Reading

References

Jan 1, 1986·Preventive Medicine·M K Chen
Jan 1, 1982·Journal of Psychiatric Research·J A YesavageV O Leirer
Sep 1, 1993·Journal of Psychosomatic Research·M T HyyppäP Puukka
Dec 11, 1999·Journal of the American Geriatrics Society·M ZamboniO Bosello
May 8, 2000·Journal of the American Geriatrics Society·S Liao, B A Ferrell
May 12, 2001·Journal of the American Geriatrics Society·J M FriedmannG L Jensen
May 22, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·O RestaG De Pergola
May 31, 2001·Journal of the American Geriatrics Society·K RockwoodI McDowell
Feb 28, 2002·Journal of Clinical Epidemiology·Anna L SchwartzMagdalena Mateo
Nov 2, 2002·Journal of the American Geriatrics Society·Kirsten Krahnstoever DavisonWilliam H Dietz
Dec 11, 2002·Journal of the American Geriatrics Society·Carolyn L TurveyRegula Herzog
Aug 7, 2003·Cancer Investigation·Shirley S HwangBasil S Kasimis
Jan 7, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·E ZoicoM Zamboni
Oct 7, 2004·American Journal of Epidemiology·Barbara J NicklasUNKNOWN Health, Aging and Body Composition Study
Nov 25, 2004·Physical Medicine and Rehabilitation Clinics of North America·Ashok PoluriAdrian Cristian
Apr 7, 2005·Molecular Aspects of Medicine·Cherian JosephGeorge A Kuchel
Jun 9, 2005·The Journal of Clinical Endocrinology and Metabolism·E O BixlerA Kales
Jul 5, 2005·Atherosclerosis·Barbara ThorandUNKNOWN KORA Group
Apr 6, 2006·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Jun 1, 2006·Menopause : the Journal of the North American Menopause Society·Corinne E I LebrunSteven W Lamberts
Jun 13, 2006·Climacteric : the Journal of the International Menopause Society·L B Tankó, C Christiansen
Sep 28, 2006·Journal of Cardiopulmonary Rehabilitation·Ross ArenaKenneth A Kraft
Dec 7, 2006·Annals of the New York Academy of Sciences·Alexandros N VgontzasGeorge P Chrousos
Jan 17, 2007·Metabolism: Clinical and Experimental·Serena TonstadIngebjørg Seljeflot
Mar 29, 2007·Journal of Thrombosis and Haemostasis : JTH·N A ZakaiM Cushman
Jun 1, 2007·Journal of the American Geriatrics Society·Sean X LengLinda P Fried
Aug 1, 2007·The Oncologist·Pascal Jean-PierreGary R Morrow
Jun 19, 2007·Journal of Occupational Health·Madelon L M van HooffToon W Taris
Sep 19, 2007·Cancer Nursing·Marian Florence Luctkar-FludeKirsten Woodend
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Jan 24, 2008·Psychosomatics·Weonjeong LimJoel E Dimsdale
Feb 13, 2008·Journal of the American Geriatrics Society·Honglei Chen, Xuguang Guo
Mar 5, 2008·Journal of the American Geriatrics Society·Hermes Florez, Bruce R Troen
Sep 10, 2008·Menopause : the Journal of the North American Menopause Society·Ming-Huei ChengJong-Ling Fuh
Sep 16, 2008·Menopause : the Journal of the North American Menopause Society·Rudy J ValentineEllen M Evans

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Citations

Oct 18, 2011·Behavior Genetics·Nicola L BarclayAlice M Gregory
Dec 19, 2013·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Bethany G EverettS Bryn Austin
Feb 19, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Dongmei LiuPaul M Gordon
Feb 9, 2016·Experimental Gerontology·Anita D ChristieJane A Kent
Mar 16, 2012·Archives of Gerontology and Geriatrics·Serife KaragozogluSahizer Eraydin
Jun 2, 2015·Journal of Psychosomatic Research·Meng-Juan JingPei-Xi Wang
Jun 12, 2012·Acta Psychiatrica Scandinavica·L L CarpenterL H Price
Jun 8, 2012·European Journal of Cancer Care·D D GuestL Q Rogers
Feb 12, 2014·Journal of the American Geriatrics Society·Nathalie de RekeneireThomas M Gill
Aug 15, 2015·Current Psychiatry Reports·Heather M DerryJanice K Kiecolt-Glaser
May 11, 2015·Sleep & Breathing = Schlaf & Atmung·Wenjie SunGuangliang Shan
Jun 23, 2011·Brain, Behavior, and Immunity·Rudy J ValentineEllen M Evans
Aug 24, 2011·Journal of Occupational and Environmental Medicine·Akinori NakataMasaya Takahashi
Oct 31, 2017·Eating and Weight Disorders : EWD·Maria C NortonFabio Lucidi
Apr 11, 2020·Behavioral Sciences·Lana Ruvolo GrasserArash Javanbakht
Aug 11, 2018·Current Psychiatry Reports·Rebecca L Ashare, Reagan R Wetherill
May 26, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Rachel CooperDiana Kuh
May 16, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Jordan N KohnSuzi Hong
Oct 23, 2019·International Journal of Molecular Sciences·Sébastien Le GarfAnne-Sophie Rousseau
Jun 13, 2021·Motor Control·Katie L KowalskiAnita D Christie

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