Sex differences in the relationship between cognitive impairment and overweight or obesity in late life: A 3-year prospective study

Medicine
Hye-Mi NohHong Ji Song

Abstract

The relationship between body weight changes in late life and cognitive function is controversial.We investigated whether weight gain or loss in late life affected cognitive function in community-dwelling older adults over a 3-year period.Our study used data from the Survey of Living Conditions and Welfare Needs of Korean Older Persons and included 3859 subjects (aged ≥65 years) with normal cognition at baseline. At baseline and the 3-year follow-up, body weight and height were measured, and cognitive function was assessed using the mini-mental state examination. Based on their body mass index (BMI) at baseline and follow-up, we divided the subjects into 4 groups: weight gain (baseline BMI <23 kg/m and follow-up BMI ≥23 kg/m); weight loss (baseline BMI ≥23 kg/m and follow-up BMI <23 kg/m); stable overweight/obese (BMI ≥23 kg/m at both visits); and stable non-overweight/obese (BMI <23 kg/m at both visits). Incidence rates (IRs) of cognitive impairment per 100 persons and IR ratios (IRRs) were calculated for each group and adjusted for confounding variables.At the 3-year follow-up, 610 cases of cognitive impairment (15.8%) were identified. The stable overweight/obese group had the lowest IR (14.0, 95% confidence interval [CI] 12....Continue Reading

References

Oct 8, 2005·The American Journal of Clinical Nutrition·Anne B NewmanTamara B Harris
Dec 20, 2005·Lancet·Cleusa P FerriUNKNOWN Alzheimer's Disease International
Jun 24, 2010·Neurobiology of Aging·April J HoUNKNOWN ADNI
Nov 9, 2010·Journal of the American Geriatrics Society·Sujuan GaoKathleen Hall
Mar 12, 2011·Obesity·Ira DriscollUNKNOWN Women's Health Initiative Study of Cognitive Aging
Oct 12, 2011·International Journal of Geriatric Psychiatry·Ada H Y LoRichard J Woodman
Mar 29, 2012·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Jian CaoXiao-ying Li
May 1, 2012·Journal of Alzheimer's Disease : JAD·Deborah R Gustafson
Jun 2, 2012·Biology of Sex Differences·Kalypso KarastergiouSusan K Fried
Mar 30, 2013·The Journal of Nutrition, Health & Aging·M GallucciC Regini
Nov 20, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A VlassopoulosM E J Lean
Sep 1, 1999·Asia Pacific Journal of Clinical Nutrition·M Deurenberg-YapW A VAN Staveren
Mar 10, 2015·Archives of Gerontology and Geriatrics·Xiaoling Xiang, Ruopeng An
Apr 14, 2015·The Lancet. Diabetes & Endocrinology·Nawab QizilbashStuart J Pocock
Oct 10, 2015·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Jong-Il ParkSang-Keun Chung
Dec 30, 2015·The Journal of Clinical Endocrinology and Metabolism·Nidia Celeste HorieCintia Cercato
Jan 25, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Giovanni ViscogliosiEvaristo Ettorre
Feb 3, 2016·JAMA Neurology·Rabe E AlhuraniRosebud O Roberts
Feb 13, 2016·PloS One·Sujin KimSang Min Park
Mar 20, 2016·Cellular and Molecular Neurobiology·Matthew J McGuire, Makoto Ishii
Jan 12, 2017·Archives of Gerontology and Geriatrics·Giovanni ViscogliosiSimona Giampaoli
Mar 2, 2017·Journal of the American Geriatrics Society·Nancy A WestBeverly G Windham
Jun 7, 2017·Journal of Alzheimer's Disease : JAD·Rosanna TortelliGiancarlo Logroscino

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Citations

Aug 17, 2019·International Journal of Geriatric Psychiatry·Young Bum Kim, Seung Hee Lee
Nov 25, 2020·Journal of Gerontological Nursing·Monique J Brown, Steven A Cohen
Apr 17, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Mark A EspelandUNKNOWN Action for Health in Diabetes (Look AHEAD) Research Group
Sep 11, 2021·Journal of Obesity & Metabolic Syndrome·Eun Mi Bae, Sang Min Park

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