Sex differences in the shared genetics of dimensions of self-reported depression and anxiety

Journal of Affective Disorders
Karen L O BurtonJustine M Gatt

Abstract

The prevalence of depression and anxiety symptoms and their comorbidity varies between males and females for reasons still unknown. This study aims to test whether differences between males and females in self-reported symptoms and their covariation are caused by variations in the magnitude of genetic and environmental factors. 750 monozygotic and dizygotic healthy twin pairs (18-60 years; M=39.77 years) participated in the TWIN-E project. Univariate and multivariate genetic modelling was undertaken using the Depression Anxiety Stress Scale (DASS-42). Additive genetics and unique environment contributed to self-reported depression (heritability, h(2): 34%), anxiety (h(2): 30%) and stress (h(2): 34%) scores in univariate models, and to the common latent factor (h(2): 39%) in the multivariate model. No sex differences in magnitude of estimates for DASS-42 scores were found in the univariate model. However when considering correlated depression and anxiety symptomatology only shared genetic factors between depression and anxiety contributed to depression scores in males, but both specific and shared genetic factors contributed to depression scores in females. The results are limited to the sample of healthy, community, adult, same...Continue Reading

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Citations

Apr 30, 2016·Journal of the American Academy of Child and Adolescent Psychiatry·Mary-Anne EnochDavid L Olds
Jun 16, 2018·The Journal of Nervous and Mental Disease·Marija Mitkovic VoncinaDusica Lecic Tosevski
Sep 2, 2018·Perspectives in Psychiatric Care·Baeth Moh'd Al-RawashdehLana Z Hubaishy

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