PMID: 8605109Mar 1, 1996Paper

Sex differences in time trends of colorectal cancer in England and Wales: the possible effect of female hormonal factors

British Journal of Cancer
I dos Santos Silva, A J Swerdlow

Abstract

Differences between the sexes in time trends of colorectal cancer incidence 1962-87 and mortality 1960-91 in England and Wales are examined in relation to changes in female hormonal factors. There was a trend in the sex ratio of this tumour, particularly marked for the descending colon, whereby the female excess in risk at young ages has almost disappeared but the male excess at older ages has increased. This trend started for cohorts born since the 1920s and coincided with the increase in the use of oral contraceptives and, to a lesser extent, with increases in fertility. The decline has been particularly pronounced for women at young ages born since 1935-39, coinciding with the spread of oral contraceptive use to younger age groups. These results are consistent with the hypothesis that female hormonal factors may play a role in the aetiology of colorectal cancer and with the possibility that oral contraceptive use might exert a protective effect in the descending colon.

Citations

Feb 16, 2006·International Journal of Cancer. Journal International Du Cancer·Tryggvi StefanssonBjarki Jónsson Eldon
Jan 16, 2007·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Miguel A SanjoaquinHenrik Møller
Jun 1, 2000·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·E FernandezE Negri
Nov 29, 2002·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·F Levi, C La Vecchia
Jul 10, 2012·International Journal of Colorectal Disease·Shih-Yung SuYung-Po Liaw
Dec 7, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Dalel Ben NéjimaMohamed Manai
Oct 24, 2002·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·E SvenssonS Tretli
Jun 23, 1999·Diseases of the Colon and Rectum·R L NelsonM Turyk
Jul 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth J Folkerd, Mitch Dowsett
Mar 15, 2018·Cadernos de saúde pública·Brenda GaspariniCosme Marcelo Furtado Passos da Silva

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