PMID: 9660308Jul 11, 1998Paper

Sex differences in voluntary drinking by Long Evans rats following early stress

Alcoholism, Clinical and Experimental Research
F E Lancaster

Abstract

Models for early stress and voluntary drinking were used to determine the contribution of early stress to increased intake of alcoholic beverages during puberty and adulthood. Newborn litters of Long Evans rats were: (1) stressed by daily separation from the mother for 15 min/day on days 1 to 7 of life ["handled" (H)]; or (2) left untouched with the mother on days 1 to 7 of life ["nonhandled" (NH)]. All animals were weaned on day 22, separated by sex (M and F), and caged individually with an assignment of 10 animals per sex per treatment group (H and NH). From 25 to 85 days of age, all animals were given free access to beer containing 5% ethanol (v/v), water, and regular laboratory food. Beer, food, and water intake was measured daily at the same time each day, and animals were weighed weekly. HM had greater ethanol intake and preference for ethanol during the peripubertal period (days 32 to 45), compared with all other groups. There were no differences in ethanol intake between NHF and NHM. HM had greater ethanol preference than HF on 22 of the 60 drinking days. HF consumed the same amount of water as the males and significantly greater amounts of water than NHF on 28 of the 60 drinking days. HM had greater ethanol preference ...Continue Reading

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Citations

Aug 19, 2011·Psychopharmacology·Howard C BeckerTamara L Doremus-Fitzwater
Apr 15, 2000·Pharmacology, Biochemistry, and Behavior·D L MckinzieA Shekhar
Nov 17, 2009·Alcohol·Joannalee C CampbellTod E Kippin
Dec 3, 2005·Stress : the International Journal on the Biology of Stress·Erika Roman, Ingrid Nylander
Aug 8, 2001·International Journal of Toxicology·B B Curry

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