Sex differences underlying orofacial varicella zoster associated pain in rats

BMC Neurology
Crystal StinsonPhillip R Kramer

Abstract

Most people are initially infected with varicella zoster virus (VZV) at a young age and this infection results in chickenpox. VZV then becomes latent and reactivates later in life resulting in herpes zoster (HZ) or "shingles". Often VZV infects neurons of the trigeminal ganglia to cause ocular problems, orofacial disease and occasionally a chronic pain condition termed post-herpetic neuralgia (PHN). To date, no model has been developed to study orofacial pain related to varicella zoster. Importantly, the incidence of zoster associated pain and PHN is known to be higher in women, although reasons for this sex difference remain unclear. Prior to this work, no animal model was available to study these sex-differences. Our goal was to develop an orofacial animal model for zoster associated pain which could be utilized to study the mechanisms contributing to this sex difference. To develop this model VZV was injected into the whisker pad of rats resulting in IE62 protein expression in the trigeminal ganglia; IE62 is an immediate early gene in the VZV replication program. Similar to PHN patients, rats showed retraction of neurites after VZV infection. Treatment of rats with gabapentin, an agent often used to combat PHN, ameliorated t...Continue Reading

References

Sep 6, 1990·The New England Journal of Medicine·R MahalingamD Gilden
Dec 1, 1995·Journal of Virology·P ClarkeD H Gilden
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·R MahalingamD H Gilden
Apr 1, 1996·Brain : a Journal of Neurology·M C Rowbotham, H L Fields
Jun 1, 1996·Neurobiology of Disease·M C RowbothamH L Fields
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·O LunguS J Silverstein
Jun 26, 1999·The Clinical Journal of Pain·M HaanpääT Nurmikko
Sep 29, 1999·The Journal of General Virology·S M Fleetwood-WalkerR G Dalziel
Apr 23, 2003·Journal of Neurovirology·Bradley M MitchellPeter G E Kennedy
Sep 29, 2004·Neurology·R M DubinskyUNKNOWN Quality Standards Subcommittee of the American Academy of Neurology
Oct 7, 2004·Brain Research. Brain Research Reviews·Robert G DalzielMargo A Mark
Jul 15, 2005·PLoS Medicine·Kathleen HempenstallAndrew S C Rice
Feb 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeffrey J Sherman, Linda LeResche
Apr 21, 2006·Supplements to Clinical Neurophysiology·G CruccuA Truini
Nov 3, 2006·Journal of Virology·Cristian CillonizWilliam T Ruyechan
Dec 19, 2006·Physiology & Behavior·Hilary D WilsonPerry N Fuchs
Jun 15, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Fábio Kurogi AlvarezJosé Tadeu Tesseroli de Siqueira
Jul 16, 2008·Brain Research·Hilary D WilsonPerry N Fuchs
Mar 20, 2009·Journal of Pain & Palliative Care Pharmacotherapy·Yvette Colon
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ada DelaneySusan M Fleetwood-Walker
Jun 23, 2010·BMC Medicine·Robert W JohnsonThomas Weinke
Nov 13, 2010·Brain Research·Cathrine BaastrupNanna Brix Finnerup
Jun 15, 2011·Journal of Dental Research·A F DaSilva, M F DosSantos
Dec 23, 2011·Journal of Neurovirology·Jason J ChenMichael D Gershon
Dec 30, 2011·Journal of Neurovirology·Paul R Kinchington, William F Goins
Jun 30, 2012·Behavioural Brain Research·Myeounghoon ChaJianguo G Gu
Jul 13, 2012·Cerebral Cortex·Xiao XiaoYu-Qiu Zhang
Aug 21, 2012·Neurochemical Research·Yan ZhangYu-Qiu Zhang

❮ Previous
Next ❯

Citations

Jul 30, 2019·Frontiers in Neuroscience·Yuanyuan DingGuangyi Zhao
Oct 30, 2018·Frontiers in Integrative Neuroscience·Phillip KramerMichael B Yee
May 20, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Cheng-Fu Wan, Tao Song

❮ Previous
Next ❯

Methods Mentioned

BETA
PEAP
biopsies

Software Mentioned

NIS
GraphPad
Envigo
Elements
Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved