Sex differentiation and sex change in the protandrous black porgy, Acanthopagrus schlegeli

General and Comparative Endocrinology
Guan-Chung WuChing-Fong Chang

Abstract

Protandrous black porgy fish, Acanthopagrus schlegeli, have a striking life cycle with a male sex differentiation at the juvenile stage and male-to-female sex change at 3 years of age. We had characterized the sex differentiation and sex change in this species by the integrative approaches of histology, endocrine and molecular genetics. The fish differentiated in gonad at the age around 4-months and the gonad further developed with a bisexual gonad for almost for 3 years and sex change at 3 year of age. An antagonistic relationship in the testicular and ovarian tissues was found during the development of the gonadal tissue. Male- (such as sf-1, dmrt1, dax-1 and amh) and female- (such as wnt4, foxl2 and cyp19a1a) promoting genes were associated with testicular and ovarian development, respectively. During gonadal sex differentiation, steroidogenic pathway and estrogen signaling were also highly expressed in the brain. The increased expression of sf-1 and wnt4, cyp19a1a in ovarian tissue and decreased expression of dax-1 in the ovarian tissue may play important roles in sex change from a male-to-female. Endocrine factors such as estradiol and luteinizing hormone may also involve in the natural sex change. Estradiol induced the ex...Continue Reading

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Citations

Jun 14, 2012·Fish Physiology and Biochemistry·Ganesan NagarajanChing-Fong Chang
Sep 20, 2015·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Talita Sarah MazzoniIrani Quagio-Grassiotto
Jan 22, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Francesc Piferrer
Jun 19, 2013·General and Comparative Endocrinology·Juan I FernandinoGustavo M Somoza
Dec 6, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Timothy S BretonDavid L Berlinsky
Aug 21, 2016·Molecular Reproduction and Development·Hui LiuNeil J Gemmell
Oct 18, 2016·Scientific Reports·Laura CasasXabier Irigoien
Nov 26, 2011·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·A AugusteM-C Chaboissier
Sep 22, 2018·International Journal of Molecular Sciences·Qing WangYong Zhang
Sep 17, 2019·Annual Review of Animal Biosciences·Oscar Ortega-RecaldeNeil J Gemmell
Feb 5, 2019·Frontiers in Genetics·Alexandros TsakogiannisCostas S Tsigenopoulos
Nov 20, 2020·Scientific Reports·M Pilar García HernándezAlfonsa García Ayala
Nov 13, 2020·Physiological Reviews·Yoshitaka NagahamaMasaru Nakamura

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