Sex-dimorphic acceleration of pericardial, subcutaneous, and plasma lipid increase in offspring of poorly nourished baboons

International Journal of Obesity : Journal of the International Association for the Study of Obesity
A H KuoG D Clarke

Abstract

Developmental programming by reduced maternal nutrition alters function in multiple offspring physiological systems, including lipid metabolism. We have shown that intrauterine growth restriction (IUGR) leads to offspring cardiovascular dysfunction with an accelerated aging phenotype in our nonhuman primate, baboon model. We hypothesized age-advanced pericardial fat and blood lipid changes. In pregnancy and lactation, pregnant baboons ate ad lib (control) or 70% ad lib diet (IUGR). We studied baboon offspring pericardial lipid deposition with magnetic resonance imaging at 5-6 years (human equivalent 20-24 years), skinfold thickness, and serum lipid profile at 8-9 years (human equivalent 32-36 years), comparing values with a normative life-course baboon cohort, 4-23 years. Increased pericardial fat deposition occurred in IUGR males but not females. Female but not male total cholesterol, low-density lipoprotein, and subcutaneous fat were increased with a trend of triglycerides increase. When comparing IUGR changes to values in normal older baboons, the increase in male apical pericardial fat was equivalent to advancing age by 6 years and the increase in female low-density lipoprotein to an increase of 3 years. We conclude that re...Continue Reading

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Citations

Aug 9, 2018·Canadian Journal of Physiology and Pharmacology·Alan H Jobe
Oct 1, 2019·Journal of Developmental Origins of Health and Disease·Hillary F HuberPeter W Nathanielsz
Jul 4, 2020·Journal of Developmental Origins of Health and Disease·Anderson H KuoGeoffrey D Clarke
Jun 18, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Diana C Castro-RodríguezElena Zambrano
Dec 4, 2020·Physiological Reviews·Daniel J HoffmanDaniel B Hardy
Dec 23, 2020·Journal of Developmental Origins of Health and Disease·G D ClarkeP W Nathanielsz
Oct 30, 2021·Comparative Medicine·Hillary F HuberGeoffrey D Clarke

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