PMID: 22552451May 4, 2012Paper

Sex, drugs, bugs, and age: rational selection of empirical therapy for outpatient urinary tract infection in an era of extensive antimicrobial resistance

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
Jaime L RochaJames R Johnson

Abstract

Optimal empirical therapy of urinary tract infection requires accurate knowledge of local susceptibility patterns, which may vary with organism and patient characteristics. Among 9,798 consecutive, non-duplicate, community-source urine isolates from ambulatory patients > 13 years old, from clinical laboratory and an academic medical center in Curitiba, Brazil (May 1st to December 1st, 2009), susceptibility data for ampicillin, nitrofurantoin, trimethoprim-sulfamethoxazole, gentamicin, fluoroquinolones, and ceftriaxone/cefotaxime were compared with organism and patient gender and age. The female-to-male ratio decreased with age, from 28.1 (among 20-29 year-olds) to 3.3 (among > 80 year-olds). Overall, susceptibility prevalence varied widely by drug class, from unacceptably low levels (53.5% and 61.1%: ampicillin and trimethoprimsulfamethoxazole) to acceptable but suboptimal levels (81.2% to 91.7%: fluoroquinolones, ceftriaxone, nitrofurantoin, and gentamicin). E. coli isolates exhibited higher susceptibility rates than other isolates, from 3-4% higher (fluoroquinolones, gentamicin) to > 30% (nitrofurantoin, ceftriaxone). Males exhibited lower susceptibility rates than females. Within each gender, susceptibility declined with inc...Continue Reading

References

Jul 13, 2002·The American Journal of Medicine·Betsy Foxman
Dec 21, 2002·Diagnostic Microbiology and Infectious Disease·Ana C GalesUNKNOWN SENTRY Participants Group (Latin America)
Apr 15, 2005·Emerging Infectious Diseases·Jesús OteoUNKNOWN Spanish members of EARSS
Mar 6, 2007·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Carlos R KifferJorge L Sampaio
Jun 15, 2007·Infection·K B LauplandD B Gregson
Jun 20, 2008·Annals of Clinical Microbiology and Antimicrobials·David C BeanDavid W Wareham
Nov 13, 2009·International Journal of Antimicrobial Agents·Ioannis KatsarolisUNKNOWN Collaborative Study Group on Antibiotic Resistance in Community-acquired Urinary Tract Infections

❮ Previous
Next ❯

Citations

Aug 9, 2013·Epidemiology and Infection·M J C SallesUNKNOWN Latin America Working Group on Bacterial Resistance
Apr 23, 2013·The Journal of Antimicrobial Chemotherapy·Heather J AdamUNKNOWN Canadian Antimicrobial Resistance Alliance (CARA)
Mar 13, 2014·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Raquel Regina BonelliRenata Cristina Picão
Sep 1, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M KreskenH Seifert
Apr 16, 2014·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Gabriel Trova CubaCarlos Roberto Veiga Kiffer
Feb 26, 2016·Revista Do Instituto De Medicina Tropical De São Paulo·Mirella Alves CunhaMarise Reis Freitas
Jul 31, 2014·Revista Do Instituto De Medicina Tropical De São Paulo·Erique José Peixoto de MirandaPaulo Andrade Lotufo
May 4, 2016·Antimicrobial Agents and Chemotherapy·Rachel McKayDavid M Patrick

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.