Sex hormone affects the severity of non-alcoholic steatohepatitis through the MyD88-dependent IL-6 signaling pathway

Experimental Biology and Medicine
Guangda XinJiangbin Wang

Abstract

Recent research has shown that the occurrence of gender disparity in liver cancer associated with sex differences in MyD88-dependent IL-6 production, but the role of this signaling pathway in sex differences of non-alcoholic steatohepatitis (NASH) remains unknown. To investigate the effects of sex hormone-specific intervention on pathology and progression of NASH, and on the inflammatory TLR-MyD88-IL-6 signaling pathway NASH was modeled in C57/BL6 mice by feeding a methionine and choline-deficient (MCD) diet for 4 weeks. Male mice were subjected to sex hormone-related interventions such as orchidectomy, and orchidectomy combined with administration of either testosterone propionate or estradiol benzoate. Next, the degree of non-alcoholic fatty liver disease activity score (NAS), serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and the expression level of MyD88 and IL-6, were compared between these groups. Males developed more serious inflammatory problems and had a higher NAS than the females. Sex-specific intervention in male mice by orchidectomy reduced NAS, ALT, and AST, and the expression level of MyD88 and IL-6. But administration of exogenous androgen had no influence on either NAS or t...Continue Reading

References

Dec 1, 1983·American Journal of Epidemiology·S KashiwagiM Kaji
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U BeckerG Jensen
Oct 11, 2003·Journal of Gastroenterology and Hepatology·Richard KirschPauline de la M Hall
Jan 22, 2004·Experimental Biology and Medicine·Pap Reddy V Kashireddy, M Sambasiva Rao
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jun 9, 2005·The Journal of Surgical Research·Yukihiro YokoyamaIrshad H Chaudry
Sep 28, 2005·Nature Immunology·Shintaro SatoShizuo Akira
May 6, 2006·The Journal of Allergy and Clinical Immunology·Tsuneyasu Kaisho, Shizuo Akira
Apr 21, 2007·Journal of Gastroenterology and Hepatology·Jian-Gao FanYan Gao
Jun 16, 2007·Gastroenterology·Hashem B El-Serag, K Lenhard Rudolph
Jul 6, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Satoru YatsujiKeiko Shiratori
Jun 19, 2008·Infection and Immunity·Elizabeth J TheveArlin B Rogers
May 21, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yanjun MuXiangdong Li
Jun 17, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yumiko AnezakiYasuo Horie
Jul 14, 2009·The Journal of Biological Chemistry·Precious G MotshweneNicholas J Gay
Apr 7, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kanji YamaguchiToshikazu Yoshikawa
Sep 2, 2010·World Journal of Gastroenterology : WJG·Nargess Ebrahimi DaryaniPeiman Habibollahi
Sep 17, 2010·Journal of Gastroenterology·Etsuko Hashimoto, Katsutoshi Tokushige
Feb 16, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kanji YamaguchiToshikazu Yoshikawa
Sep 3, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yoshihiro KamadaTetsuo Takehara
Jan 14, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G-X TianZ-N Mo
May 10, 2012·Gut and Liver·Geoffrey C FarrellShivrakumar Chitturi
Jul 24, 2013·Journal of Gastroenterology and Hepatology·Yoon Seok Roh, Ekihiro Seki

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Citations

Aug 23, 2016·International Journal of Molecular Sciences·Maximilian NeumannChrista Buechler
Nov 1, 2018·Anais Da Academia Brasileira De Ciências·Denilsa P FernandesMarcelo B Bezerra
Apr 12, 2019·Combinatorial Chemistry & High Throughput Screening·Xiang LiuYing Zhang
Oct 28, 2015·Journal of Experimental & Clinical Cancer Research : CR·Lei DengBeicheng Sun
Sep 27, 2019·Nature Reviews. Drug Discovery·Claire Vanpouille-BoxLorenzo Galluzzi
Apr 26, 2017·Proceedings of the National Academy of Sciences of the United States of America·James A RogersV Wee Yong
Dec 22, 2019·Journal of Clinical Medicine·Giovanni TarantinoDomenico Capone
Oct 22, 2020·International Journal of Molecular Sciences·Akash AhujaJae Youl Cho

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
PCR
electrophoresis

Software Mentioned

SPSS19

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