PMID: 6537912Jan 1, 1984Paper

Sex hormone binding globulin (SHBG) in breast cancer: a correlation with obesity but not with estrogen receptor status

European Journal of Cancer & Clinical Oncology
A SulkesJ Gross

Abstract

Plasma sex hormone binding globulin (SHBG) levels were determined in a group of 82 patients suffering from breast carcinoma with a known estrogen receptor status (ER). Overweight (greater than 20% of ideal weight) premenopausal patients had a significantly lower SHBG plasma level than their non-obese counterparts (43 pmol/ml vs 72.7 pmol/ml, P less than 0.001). No difference in plasma levels of SHBG was found between obese and non-obese postmenopausal patients. No correlation was found between SHBG levels and ER status either in non-obese premenopausal patients or in postmenopausal patients in general. Breast carcinoma patients had significantly higher SHBG plasma levels than a group of normal controls (57.9 pmol/ml vs 40.6 pmol/ml, P less than 0.01), but the stage of the disease did not influence the SHBG level within the breast carcinoma patients. Results of this study do not support a correlation between SHBG levels and ER status. SHBG plasma levels are significantly influenced by a patient's weight, particularly in those who are premenopausal.

References

Jun 1, 1978·The Journal of Clinical Endocrinology and Metabolism·Y MurayamaK Asano
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Citations

Mar 3, 2007·Pediatric Annals·Steven P Shelov
Jan 1, 1988·Annals of the New York Academy of Sciences·R D BulbrookD Y Wang
Feb 2, 2017·Theoretical Biology & Medical Modelling·Xiong Li, Wen Jiang
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Jan 9, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Gulay BulutIrfan Bayram
Jul 1, 1987·The Proceedings of the Nutrition Society·E M Whitaker

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