Sex hormone-binding globulin stimulates chorionic gonadotrophin secretion from human cytotrophoblasts in culture

Human Reproduction
G QueipoF Larrea

Abstract

The effects of sex hormone-binding globulin (SHBG) on the secretion of human chorionic gonadotrophin (HCG) and cAMP by cultured human cytotrophoblasts were investigated. Cytotrophoblasts obtained from normal term placentae were cultured in serum-free medium with or without the addition of human SHBG. The presence of SHBG in the medium increased the release of HCG and the accumulation of cAMP. Ligand-free SHBG was able to raise both HCG and cAMP concentrations and the maximal response was observed with 1 nM of the steroid-binding globulin. Addition of either oestradiol or 5alpha-dihydro-testosterone (DHT) to cultures previously incubated with SHBG in a final molar ratio of 1:10 resulted in a further increase of HCG and cAMP concentrations. This effect was blocked when cultured placental cells were exposed to SHBG that was previously saturated with DHT or when incubated in the presence of steroids only. The results of the present study provide evidence for the in-vitro regulation of HCG secretion by SHBG and further support the concept that this steroid-binding protein may act as a mediator of steroid action at the cellular level. Finally, the increase in cAMP suggests that SHBG receptor located in the surface of syncytiotrophobl...Continue Reading

Citations

Feb 8, 2003·Molecular and Cellular Endocrinology·Julie Della-MariaHubert Gerard
Nov 22, 2011·Journal of Perinatal Medicine·Lei SunPinting Wang
Aug 25, 2009·Molecular and Cellular Endocrinology·William RosnerNicholas A Romas
Jun 27, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Zhen JinWeiwei Li

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