Sex hormone replacement therapy for individuals with Turner syndrome

American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
Philippe F Backeljauw, Karen O Klein

Abstract

Turner syndrome is a relatively common genetic condition resulting from absence of all or part of the second sex chromosome. Individuals with Turner syndrome commonly exhibit cardiovascular, endocrine, renal, reproductive, and/or psychosocial abnormalities, among other conditions. Most girls with Turner syndrome have hypergonadotropic hypogonadism and therefore need sex steroid hormonal replacement therapy. The optimal estrogen replacement treatment regimen to induce pubertal development is still being determined. The goals of the estrogen replacement are to mimic the normal physical and social development for timing and progression of puberty. Treatment should begin at 11-12 years of age, with dose increases every 6 months over a 2-3 year period. Initiation with low doses of estrogen is crucial to preserve growth potential. On the other hand, delaying estrogen replacement may be deleterious to bone and uterine health.

References

Mar 1, 1996·The Journal of Clinical Endocrinology and Metabolism·J L RossG B Cutler
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·S PiippoI Sipilä
Oct 19, 2006·The Journal of Clinical Endocrinology and Metabolism·Carolyn A Bondy, UNKNOWN Turner Syndrome Study Group
Mar 29, 2007·Journal of Clinical Pharmacology·Damayanthi DevineniAlbert T Leung
Aug 23, 2007·The Journal of Clinical Endocrinology and Metabolism·Nelly MaurasSusan Welch
Mar 26, 2009·The Journal of Clinical Endocrinology and Metabolism·Zeina M NabhanErica A Eugster
Jun 9, 2010·BMJ : British Medical Journal·Christel RenouxSamy Suissa
Apr 1, 2011·The New England Journal of Medicine·Judith L RossGordon B Cutler
Jun 24, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Madhusmita MisraAnne Klibanski
Jul 28, 2011·Hormone Research in Pædiatrics·Line CleemannClaus H Gravholt
Dec 8, 2011·Endocrine·Christian TrolleClaus H Gravholt
Sep 12, 2012·Journal of Thrombosis and Haemostasis : JTH·S SweetlandUNKNOWN Million Women Study Collaborators
May 17, 2013·The Journal of Clinical Endocrinology and Metabolism·L Torres-SantiagoN Mauras
May 15, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Esra D P ÇakırÖmer F Tarım
Nov 7, 2015·The Journal of Clinical Endocrinology and Metabolism·Khaled MohammedMohammad Hassan Murad
Nov 5, 2016·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine. Electronic address: ASRM@asrm.org, UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Nov 25, 2016·European Journal of Endocrinology·Line CleemannClaus H Gravholt
Jul 15, 2017·European Journal of Endocrinology·Claus H GravholtUNKNOWN International Turner Syndrome Consensus Group

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Citations

Aug 17, 2019·American Journal of Medical Genetics. Part a·Angela E LinClaus H Gravholt
Aug 12, 2021·São Paulo Medical Journal = Revista Paulista De Medicina·Maurício Rouvel NunesRafael Fabiano Machado Rosa
Dec 12, 2021·The Journal of Clinical Endocrinology and Metabolism·Nandini VijayakanthiDoris Fadoju

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