Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods

Frontiers in Neuroscience
Claudia BarthJulia Sacher

Abstract

Sex hormones have been implicated in neurite outgrowth, synaptogenesis, dendritic branching, myelination and other important mechanisms of neural plasticity. Here we review the evidence from animal experiments and human studies reporting interactions between sex hormones and the dominant neurotransmitters, such as serotonin, dopamine, GABA and glutamate. We provide an overview of accumulating data during physiological and pathological conditions and discuss currently conceptualized theories on how sex hormones potentially trigger neuroplasticity changes through these four neurochemical systems. Many brain regions have been demonstrated to express high densities for estrogen- and progesterone receptors, such as the amygdala, the hypothalamus, and the hippocampus. As the hippocampus is of particular relevance in the context of mediating structural plasticity in the adult brain, we put particular emphasis on what evidence could be gathered thus far that links differences in behavior, neurochemical patterns and hippocampal structure to a changing hormonal environment. Finally, we discuss how physiologically occurring hormonal transition periods in humans can be used to model how changes in sex hormones influence functional connecti...Continue Reading

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References

Jun 1, 1977·Journal of Neurochemistry·V N Luine, B S McEwen
Apr 1, 1976·The British Journal of Psychiatry : the Journal of Mental Science·P N NottM G Gelder
Jan 1, 1991·Archives of Internal Medicine·R R WingP L Plantinga
Apr 1, 1991·Trends in Pharmacological Sciences·B S McEwen
Jan 1, 1990·Annals of the New York Academy of Sciences·A Biegon
Aug 31, 1988·Neuroscience Letters·J De KeyserG Vauquelin
Nov 1, 1983·Archives of General Psychiatry·J H KashaniD H McKnew
Dec 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·H HallL Farde
Jul 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·P M LewinsohnP Rohde
Aug 17, 1995·Nature·G V Williams, P S Goldman-Rakic
Jan 1, 1993·Journal of Molecular Neuroscience : MN·C R Breese, S S Leonard
Jan 1, 1994·Reviews in the Neurosciences·T Di Paolo
Apr 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·A G HayE C Johnstone
Sep 1, 1993·Neuron·R RupprechtF Holsboer
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Feb 1, 1996·Archives of General Psychiatry·D P DevanandR Mayeux
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·K F BermanD R Weinberger
May 1, 1997·Journal of Psychiatric Research·R Rupprecht
Jan 22, 1998·The New England Journal of Medicine·P J SchmidtD R Rubinow
Apr 29, 1998·Brain Research. Molecular Brain Research·M Pecins-ThompsonC L Bethea
Mar 4, 1998·Psychological Medicine·A AngoldC M Worthman
Apr 1, 1998·Proceedings of the Society for Experimental Biology and Medicine·W B Pratt
Apr 29, 1998·Progress in Neurobiology·S OzawaK Tsuzuki
May 26, 1998·European Journal of Pharmacology·K A DisshonD E Dluzen
Nov 10, 1998·Biological Psychiatry·H Joffe, L S Cohen
Nov 10, 1998·Biological Psychiatry·D R RubinowC A Roca
Feb 26, 1999·Journal of Neurophysiology·M R FoyT W Berger

❮ Previous
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Citations

Aug 21, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mary V Seeman
Aug 8, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julian MacoveanuHartwig R Siebner
Feb 18, 2016·Neural Plasticity·Alessandra Aparecida MarquesGisele Pereira Dias
Mar 5, 2016·Psychoneuroendocrinology·D S StenbækV G Frokjaer
Apr 29, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Oscar V Torres, Laura E O'Dell
Dec 5, 2015·Frontiers in Psychiatry·Valeria Hansberg-PastorIgnacio Camacho-Arroyo
Oct 7, 2015·Frontiers in Endocrinology·Danaé NuzzaciAlexandre Benani
Aug 12, 2015·NeuroImage·Julie HamaideAnnemie Van der Linden
May 18, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Gerd WagnerKarl-Jürgen Bär
May 4, 2016·Psychopharmacology·Inga Griskova-BulanovaOsvaldas Ruksenas
May 12, 2016·Neuroscience and Biobehavioral Reviews·I García-GarcíaJ Neumann
Oct 21, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Patrick MacDonald FisherVibe Gedsoe Frokjaer
Oct 8, 2016·Scientific Reports·Claudia BarthJulia Sacher
Mar 23, 2017·Frontiers in Behavioral Neuroscience·Florian Duclot, Mohamed Kabbaj
Mar 3, 2017·Journal of Cognitive Neuroscience·Lisa Marieke KluenLars Schwabe
Jun 27, 2017·NPJ Microgravity·Angelique Van OmbergenFloris L Wuyts
Mar 6, 2018·Current Psychiatry Reports·Sarah L FerriEdward S Brodkin
Dec 28, 2017·Addiction Biology·Almila ErolVictor M Karpyak
Feb 10, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Francesca ZanderigoJ John Mann
Jul 19, 2018·Development and Psychopathology·Jerome Kagan
Oct 9, 2018·The New Bioethics : a Multidisciplinary Journal of Biotechnology and the Body·Jocelyn Downey
Oct 28, 2018·Pediatric Research·Ivo BendixUrsula Felderhoff-Müser
Oct 24, 2018·Radiology·Patrizia A ChiesaUNKNOWN INSIGHT-preAD Study Group and the Alzheimer Precision Medicine Initiative (APMI)
Mar 6, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Klara SpalekAnnette Milnik
Apr 27, 2019·Depression and Anxiety·Yu-Chih ShenDah-Ching Ding
Jun 14, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Belinda PletzerEsmeralda Hidalgo-Lopez
Jul 4, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Alessandra GraziottinGenevieve Hall
Nov 21, 2018·The British Journal of Psychiatry : the Journal of Mental Science·Divya MehtaVibe G Frokjaer
Feb 28, 2018·Brain and Behavior·Alexandra Miranda, Nuno Sousa
Nov 21, 2019·Clinical & Experimental Ophthalmology·Anne X Nguyen, Albert Y Wu
Feb 20, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Timothy C HutchersonMeaghan F Gosciak
Mar 7, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Ugur DamarAlexander Rotenberg
Nov 7, 2019·The Journal of Clinical Endocrinology and Metabolism·Hadine JoffeJanet E Hall
Mar 24, 2020·Molecular Reproduction and Development·Susanta K BehuraThomas E Spencer

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Methods Mentioned

BETA
contraception

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