Sex hormones and brain volumes in a longitudinal study of middle-aged men in the CARDIA study.

Brain and Behavior
Martine ElbejjaniLenore J Launer

Abstract

Several findings suggest that testosterone (T) is neuroprotective and that declining T levels during aging are associated with cognitive and brain pathologies; however, little is known on T and brain health in middle-age. We examined the relationships of total T, bioavailable T, and sex hormone binding globulin (SHBG) levels with total and regional gray matter (GM) and white matter (WM) volumes in middle-aged men. We also evaluated the association of sex hormone levels with cognitive function. Analysis included 267 community-dwelling men participating in the Coronary Artery Risk Development in Young Adults (CARDIA) brain magnetic resonance imaging (MRI) substudy. Total T, bioavailable T, and SHBG levels were measured at three times from the 2nd to 4th decade of life; brain volumes were measured at the ages of 42-56. Associations were estimated using linear regression models, adjusted for several potential confounders. Higher SHBG levels were associated with greater total WM volume (+3.15 cm3 [95% confidence interval [CI] = 0.01, 6.28] per one standard deviation higher SHBG). Higher SHBG levels were associated with lower total and regional GM volumes overall and significantly with smaller parietal GM volume (-0.96 cm3 [95%CI = -...Continue Reading

References

Jan 1, 1988·Journal of Clinical Epidemiology·G D FriedmanP J Savage
Jun 9, 1998·IEEE Transactions on Medical Imaging·J G SledA C Evans
Oct 1, 1998·Journal of Computer Assisted Tomography·A F GoldszalS M Resnick
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A VermeulenJ M Kaufman
Dec 22, 1999·International Journal of Epidemiology·P RoystonW Sauerbrei
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·G K GourasP Greengard
May 2, 2002·Journal of the American Geriatrics Society·Kristine YaffeJane Cauley
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Scott D MoffatSusan M Resnick
Feb 11, 2003·IEEE Transactions on Medical Imaging·Dinggang Shen, Christos Davatzikos
May 28, 2004·Clinical Endocrinology·Carolyn A Allan, Robert I McLachlan
Oct 29, 2004·The Journal of Clinical Endocrinology and Metabolism·Willem de RondeFrank H de Jong
Dec 8, 2004·Experimental Gerontology·E HogervorstA D Smith
Feb 28, 2006·Neurobiology of Aging·Dorothea StrozykLenore J Launer
May 12, 2006·Nature Reviews. Neuroscience·Larry Cahill
Jul 22, 2008·International Journal of Geriatric Psychiatry·Faith M Gunning-DixonGeorge S Alexopoulos
Oct 29, 2008·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J D Caldwell, G F Jirikowski
Nov 22, 2008·Neurobiology of Aging·Majon MullerJosé A Luchsinger
May 23, 2009·Brain : a Journal of Neurology·Rahul S DesikanUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 30, 2010·Clinical Endocrinology·Lam P LyDavid J Handelsman
Apr 27, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Carolyn A Allan, Robert I McLachlan
May 25, 2010·Human Brain Mapping·Sarah-Jayne BlakemoreRonald E Dahl
Dec 7, 2010·Brain and Cognition·Heidi I L JacobsJelle Jolles
Jun 24, 2011·Maturitas·J HollandE Hogervorst
Feb 16, 2012·Gender Medicine·Joel SalinasPeg Nopoulos
May 18, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jiska S Peper, P Cédric M P Koolschijn
Oct 24, 2012·Molecular Psychiatry·G VerdileUNKNOWN AIBL Research Group
Nov 10, 2013·Academic Radiology·Jimit DoshiChristos Davatzikos
Mar 4, 2014·Current Cardiology Reports·Catherine Kim, Jeffrey B Halter
Jun 15, 2014·Magnetic Resonance Imaging·Chunming LiChristos Davatzikos
Apr 17, 2015·Ultrastructural Pathology·Yaqing LiZhenhe Suo

❮ Previous
Next ❯

Citations

Dec 20, 2018·Brain Plasticity·A M FernandezI Torres Aleman
Dec 14, 2018·Journal of Neurosurgery·Alana Tooze, Jason P Sheehan
Feb 26, 2019·Therapeutic Hypothermia and Temperature Management·Travis C Jackson, Patrick M Kochanek

❮ Previous
Next ❯

Methods Mentioned

BETA
blood draw
equilibrium dialysis

Software Mentioned

SAS
CARDIA

Related Concepts

Related Feeds

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.