Sex Hormones and Cognition: Where Do We Stand?

Journal of Obstetrics and Gynaecology of India
Satish V Khadilkar, Varsha A Patil

Abstract

Hypothalamic-pituitary-gonadal axis regulates the reproductive system. The overall health and wellbeing of a woman is subject to fluctuations in the sex hormones throughout her lifespan. Menopause, either natural or surgically induced, is often associated with cognitive complaints, especially memory disturbances. Sex hormones, besides affecting the reproductive function, affect the central nervous system in many ways. Here, we aim to review the role of sex hormones in cognition and the current evidence on use of or against menopausal hormonal therapy as a cognition enhancer in women with cognitive disturbances, including those with Alzheimer's disease.

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Citations

Aug 28, 2021·International Journal of Molecular Sciences·Yu-Jung ChengHsien-Yuan Lane

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