Sex hormones and incident dementia in older men: The health in men study

Psychoneuroendocrinology
Andrew H FordOsvaldo P Almeida

Abstract

Low circulating testosterone has been associated with dementia in older men but existing evidence from prospective studies is inconsistent. We conducted a prospective longitudinal study of 4069 community-dwelling older men free of dementia aged 71-88 years at baseline. The main objective of the study was to determine if men with low circulating sex hormones were more likely to develop dementia over time. The main biochemical exposures of interest were collected at baseline between 2001 and 2004 and men were assessed for incident dementia via an electronic health records database to the 31 st of December 2013. Dementia developed in 499 men over a median of 10.5 years (range 9.4-12.2 years). The risk of developing dementia increased with decreasing total (hazard ratio [HR] 1.14, 95% confidence interval [95%CI] 1.03-1.26 per standard deviation decrease) and calculated free testosterone (HR 1.18, 95%CI 1.06-1.31 per standard deviation decrease) after adjustment for age, baseline cognitive function, depression, body mass, hypertension, cardiovascular disease and total plasma homocysteine. Men in the lowest quartiles of total (adjusted HR 1.39, 95%CI 1.04-1.85) and calculated free testosterone (adjusted HR 1.43, 95%CI 1.08-1.90) had ...Continue Reading

Citations

Jul 2, 2020·Biology of Sex Differences·Charly Abi-GhanemKristen L Zuloaga
Dec 8, 2020·Frontiers in Endocrinology·Zhonglin Cai, Hongjun Li
Jan 4, 2022·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ross J MarriottBu B Yeap

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