Sex Hormones and Optic Nerve Disorders: A Review

Frontiers in Neuroscience
Raffaele NuzziGiancarlo Panzica

Abstract

Aim: This review article presents a comprehensive overview of the literature on sex hormones (estrogens, androgens, progesterone) and optic nerve disorders, with a discussion of the implications for therapy and prevention. Methods: Epidemiological, pre-clinical and clinical studies were reviewed. Results: Analysis of the biological basis for a relationship between eye diseases and sex hormones showed that some types of hormones can exert a protective effect either directly on the retina and optic nerve or indirectly by modulating ocular blood flow. For example, it seems that estrogen exposure has a protective effect against glaucoma, whereas its deficit may lead to early onset of the disease. If further studies confirm the data in the literature, estrogen therapy, because of its antioxidant action, may be effective in the treatment of Leber's hereditary optic neuropathy, whereas, in the light of current studies, there does not seem to be an influence of estrogen on non-arteritic anterior ischemic optic neuritis (NAION). Conclusions: Although there is some evidence that in some optic nerve pathologies the sex hormones seem to play an important role there are still too few studies providing evidence for its wider use in clinical ...Continue Reading

References

Jan 1, 1990·Diabetes Care·B E KleinR Klein
Dec 1, 1974·The British Journal of Ophthalmology·S S Hayreh
Oct 1, 1996·Acta Obstetricia Et Gynecologica Scandinavica·I A QureshiX D Wu
Dec 10, 1997·Maturitas·M O SatorJ C Huber
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·B Moosmann, C Behl
Dec 28, 1999·The British Journal of Ophthalmology·E M RochaD A Sullivan
May 4, 2000·Acta Ophthalmologica Scandinavica·L A WickhamD A Sullivan
Jun 26, 2001·The British Journal of Ophthalmology·C MunautJ M Rakic
Jul 12, 2001·American Journal of Epidemiology·C A HulsmanP T de Jong
Sep 27, 2002·Annals of Neurology·Nancy L SicotteRhonda R Voskuhl
Jan 9, 2003·American Journal of Human Genetics·P Yu-Wai-ManP F Chinnery
Nov 12, 2003·The British Journal of Ophthalmology·A J LeeUNKNOWN Blue Mountains Eye Study
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Samantha S SoldanRhonda R Voskuhl
Dec 4, 2003·Acta Ophthalmologica Scandinavica·Ebru TokerHaluk Kazokoglu
Feb 10, 2004·Progress in Retinal and Eye Research·Valerio CarelliAlfredo A Sadun
Mar 3, 2004·Annals of the New York Academy of Sciences·P GuarneriR Guarneri
Mar 9, 2004·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Ozgül AltintaşLevent Karabaş
May 26, 2004·Lancet·Robert N Weinreb, Peng Tee Khaw
Dec 21, 2004·Acta Ophthalmologica Scandinavica·Munire Erman AkarYusuf Akar
Jan 4, 2005·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Yusuf AkarEylem Seker Ari
Apr 27, 2005·Survey of Ophthalmology·P D GuptaA R Vasavada
Jul 29, 2005·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Munire Erman AkarYusuf Akar
Nov 1, 2005·Experimental Eye Research·Pedro Beneyto, Teresa M Pérez
May 18, 2006·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Sushma SharmaGabrielle Downey
Jun 21, 2006·Endocrine·Anna CzłonkowskaIwona Kurkowska-Jastrzebska
Sep 4, 2008·Cancer Causes & Control : CCC·Martha J FeliniMargaret Wrensch
Dec 2, 2008·Nature Clinical Practice. Neurology·Elliot M FrohmanLaura J Balcer
Mar 24, 2009·Current Neuropharmacology·K-G SchmidtR H W Funk
Sep 11, 2009·Journal of the Neurological Sciences·Dean M Wingerchuk
Dec 19, 2009·Investigative Ophthalmology & Visual Science·Micheline C DeschênesMark R Lesk
Jul 20, 2010·Archives of Biochemistry and Biophysics·Bart L Clarke, Sundeep Khosla
Aug 31, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Dominique S MichaudElio Riboli
Oct 15, 2010·Brain : a Journal of Neurology·Carla GiordanoValerio Carelli
Apr 8, 2011·Menopause : the Journal of the North American Menopause Society·Alice Fátima Melgaço FariaSelmo Geber
Jun 28, 2011·Neuroscience·R C MelcangiL M Garcia-Segura
Sep 6, 2011·Trends in Endocrinology and Metabolism : TEM·Iñigo AzcoitiaLuis M Garcia-Segura
Mar 15, 2012·Menopause : the Journal of the North American Menopause Society·Thasarat S Vajaranant, Louis R Pasquale
Jun 16, 2012·Investigative Ophthalmology & Visual Science·Everett Nixon, James W Simpkins
Oct 11, 2012·Climacteric : the Journal of the International Menopause Society·M A M De SouzaS Geber
Oct 30, 2012·Journal of Neurosurgery·Elizabeth B ClausJoellen M Schildkraut

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Citations

Nov 23, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Pınar Bingöl KızıltunçHuban Atilla
Aug 15, 2019·Investigative Ophthalmology & Visual Science·Rui HuaLimin Liu
Feb 23, 2020·Frontiers in Behavioral Neuroscience·Caitlin E LeslieHamilton E Farris
Nov 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katalin Prokai-Tatrai, Laszlo Prokai
Apr 15, 2020·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Barbara R Migeon
Oct 22, 2020·European Journal of Ophthalmology·Abdulmutalip YildirimYildiz Uyar
Feb 13, 2021·Journal of Diabetes Research·Qingmin SunYaping Wang
Jun 24, 2021·British Journal of Clinical Pharmacology·Kate HogdenMahyar Etminan
Jul 26, 2021·International Journal of Pharmaceutics·Adrián M Alambiaga-CaravacaAlicia López-Castellano
Oct 14, 2021·Investigative Ophthalmology & Visual Science·Maria J RodrigoElena Garcia-Martin

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Methods Mentioned

BETA
hormone replacement therapy
hysterectomy

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