PMID: 9161687Mar 1, 1997Paper

Sex hormones and the thymus in relation to thymocyte proliferation and maturation

Archives of Histology and Cytology
K Seiki, K Sakabe

Abstract

This paper reviews the mechanism of sex hormone actions on the thymus, presenting mainly our data obtained at the cellular and molecular levels. First, data supporting the "genomic" action via the nuclear sex hormone receptor complexes are as follows: 1) sex hormone receptors and the thymic factor (thymulin) are co-localized in thymic epithelial cells, but not in T cells; 2) production/expression of thymic factors (thymulin, thymosin alpha 1) are remarkably inhibited by sex hormone treatment; 3) sex hormones cause changes in T cell subpopulations in the thymus; and 4) sex hormones strongly influence the development of thymus tumors in spontaneous thymoma BUF/Mna rats through their receptor within the tumor cells. Secondly, data indicating the "non-genomic" action of sex hormones via a membrane signal-generating mechanism are as follows: 1) the proliferation/maturation of thymic epithelial cells is mediated through protein kinase C activity introduced by sex hormones; 2) sex hormones directly influence DNA synthesis and cdc2 kinase (cell cycle-promoting factor) activity.

Citations

May 12, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Karen A GouldJames D Shull
Feb 26, 2000·International Journal of Immunopharmacology·B BodeyH E Kaiser
Feb 13, 2001·Molecular and Cellular Endocrinology·K A GouldJ Gorski
Jul 18, 2002·Toxicology Letters·Humitoshi SakazakiKatsuhiko Nakamuro
May 23, 2001·International Immunopharmacology·G LeposavićB Vidić-Danković
Jul 4, 2001·Clinical Microbiology Reviews·C W RobertsJ Alexander
Dec 27, 2013·Clinical & Developmental Immunology·Xiao-Kai GuoJun Zhang
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·T A TibbettsB W O'Malley
Mar 19, 2003·International Journal of Experimental Pathology·Kazunori KikuchiTakashi Yoshiki
Dec 1, 2001·Expert Opinion on Biological Therapy·B Bodey
Jul 12, 2005·General and Comparative Endocrinology·B Hareramadas, U Rai
Mar 21, 2002·Expert Opinion on Therapeutic Targets·Bela Bodey
Jul 31, 2012·The Journal of Nutritional Biochemistry·M L Lazo de la Vega-MonroyC Fernandez-Mejia
Mar 5, 1999·Clinical and Experimental Pharmacology & Physiology·S SaitoP W Ramwell
Apr 25, 2003·International Journal of Cancer. Journal International Du Cancer·Eric A Engels, Ruth M Pfeiffer
Feb 1, 2019·Toxicologic Pathology·Yuki TomonariMinoru Tsuchitani
Mar 24, 2005·Neuroimmunomodulation·Gordana LeposavićDusko Kosec
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Hironori IshibashiHironobu Sasano
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hong-biao LiuRhonda R Voskuhl
Jan 19, 2021·Developmental and Comparative Immunology·Catarina MoreiraTiphaine Monsinjon
Jun 30, 2016·Acta Microbiologica Et Immunologica Hungarica·György Csaba

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