Sex hormones and venous thromboembolism - from contraception to hormone replacement therapy

VASA. Zeitschrift für Gefässkrankheiten
Jan Beyer-WestendorfHannelore Rott

Abstract

The use of sex hormones such as combined oral contraceptives (COC) or hormone replacement therapy (HRT) increases the risk for venous thromboembolism (VTE) considerably, especially in patients with an increased intrinsic risk for thromboembolic complications. Despite public and media attention and increasing scientific evidence, prescription patterns seem to be hard to change. It is well recognized that the patient's baseline risk is the most relevant factor in the absolute risk for developing VTE. The relative risk increase associated with sex hormones, depends on the type and dosage of hormones, the route of application (oral, vaginal, transdermal), and for COC, on the specific combination of oestrogen and gestagen components. Consequently, a careful decision for or against any specific type of hormone treatment needs to be based on an assessment of the patient's risk profile (disposition) as well as on the treatment-associated risks and benefits (exposition). This review discusses the most common sex hormone treatments in contraception and HRT, the relevance for VTE risk patients, and strategies to counsel patients with regard to hormone use according to their risk profiles. Keywords: Oral contraceptives, hormonal contracept...Continue Reading

References

Nov 27, 1986·The New England Journal of Medicine·I Iturbe-AlessioE Salazar
Mar 15, 1997·BMJ : British Medical Journal·S Pérez GutthannA Duque Oliart
May 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·H J TeedeR E Peverill
Jul 21, 2001·BMJ : British Medical Journal·J M KemmerenD E Grobbee
Jun 18, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·David M HerringtonStephen B Hulley
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
May 29, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Kwang Kon KohEak Kyun Shin
Oct 7, 2004·JAMA : the Journal of the American Medical Association·Mary CushmanUNKNOWN Women's Health Initiative Investigators
Oct 7, 2004·JAMA : the Journal of the American Medical Association·Nicholas L SmithBruce M Psaty
Nov 23, 2005·Circulation·Céline StraczekUNKNOWN Estrogen and Thromboembolism Risk (ESTHER) Study Group
May 30, 2006·Thrombosis and Haemostasis·Christof SchaeferPaul Merlob
Feb 21, 2007·Circulation·Marianne CanonicoUNKNOWN Estrogen and Thromboembolism Risk (ESTHER) Study Group
Apr 17, 2007·Contraception·Lothar A J Heinemann, Jürgen C Dinger
Nov 7, 2008·The New England Journal of Medicine·Paul E Marik, Lauren A Plante
Oct 17, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Marianne CanonicoPierre-Yves Scarabin
Aug 27, 2010·Journal of Thrombosis and Haemostasis : JTH·S C ChristiansenS C Cannegieter
Aug 28, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Astrid van Hylckama VliegFrits R Rosendaal
Feb 23, 2011·Journal of Thrombosis and Thrombolysis·Saskia Middeldorp
Nov 18, 2011·Menopause : the Journal of the North American Menopause Society·Daniela Amorim Melgaço GuimarãesAna Paula Fernandes
Dec 8, 2011·British Journal of Haematology·Alyshah Abdul SultanMatthew J Grainge
Jan 14, 2012·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Francisca MartínezIñaki Lete
May 12, 2012·BMJ : British Medical Journal·Ojvind LidegaardEllen Løkkegaard
Jun 19, 2012·Thrombosis Research·Annica BergendalHelle Kieler
Sep 12, 2012·Journal of Thrombosis and Haemostasis : JTH·S SweetlandUNKNOWN Million Women Study Collaborators
Nov 10, 2012·Journal of Thrombosis and Haemostasis : JTH·R E J RoachA van Hylckama Vlieg
Aug 2, 2013·The Cochrane Database of Systematic Reviews·Ginette M GoossenMarianne D van de Wetering
Dec 18, 2013·Journal of Thrombosis and Haemostasis : JTH·H N HolmegardM Benn
Feb 20, 2014·Journal of Thrombosis and Haemostasis : JTH·L EischerP A Kyrle
Mar 5, 2014·The Cochrane Database of Systematic Reviews·Marcos de BastosOlaf M Dekkers
Mar 19, 2014·Journal of Thrombosis and Haemostasis : JTH·M BlondonN L Smith
Jul 22, 2014·Journal of Thrombosis and Haemostasis : JTH·R A van AdrichemS C Cannegieter

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Methods Mentioned

BETA
contraception
hormone replacement treatment
contraceptions

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