Sex hormones in allergic conjunctivitis: altered levels of circulating androgens and estrogens in children and adolescents with vernal keratoconjunctivitis

Journal of Immunology Research
Marta SacchettiStefano Bonini

Abstract

Vernal keratoconjunctivitis (VKC) is a chronic allergic disease mainly affecting boys in prepubertal age and usually recovering after puberty. To evaluate a possible role of sex hormones in VKC, serum levels of sex hormones in children and adolescents with VKC were assessed. 12 prepubertal and 7 early pubertal boys with active VKC and 6 male patients with VKC in remission phase at late pubertal age and 48 healthy age and sex-matched subjects were included. Serum concentration of estrone, 17 beta-estradiol, dehydroepiandrosterone-sulfate, total testosterone and free testosterone, dihydrotestosterone (DHT), cortisol, delta-4-androstenedione, follicle-stimulating hormone, luteinizing hormone, and sex-hormones binding globuline (SHBG) were evaluated. Serum levels of Estrone were significantly increased in all groups of patients with VKC when compared to healthy controls (P < 0.001). Prepubertal and early pubertal VKC showed a significant decrease in DHT (P = 0.007 and P = 0.028, resp.) and SHBG (P = 0.01 and P = 0.002, resp.) when compared to controls and serum levels of SHBG were increased in late pubertal VKC in remission phase (P = 0.007). VKC patients have different circulating sex hormone levels in different phases of the dise...Continue Reading

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Citations

Jul 18, 2020·Current Opinion in Allergy and Clinical Immunology·Antonio Di ZazzoMerle Fernandes
Jun 9, 2016·Open Access Macedonian Journal of Medical Sciences·Violeta Lokaj-BerishaSanije Gashi-Hoxha
Jul 29, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Heba AleneziNicole Carnt
Nov 11, 2021·Allergy·Neera SinghAndrea Leonardi

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