Abstract
The association between sex hormones and sex hormone binding globin (SHBG) with vertebral fractures in men is not well studied. In these analyses, we determined whether sex hormones and SHBG were associated with greater likelihood of vertebral fractures in a prospective cohort study of community dwelling older men. We included data from participants in MrOS who had been randomly selected for hormone measurement (N=1463, including 1054 with follow-up data 4.6years later). Major outcomes included prevalent vertebral fracture (semi-quantitative grade≥2, N=140, 9.6%) and new or worsening vertebral fracture (change in SQ grade≥1, N=55, 5.2%). Odds ratios per SD decrease in sex hormones and per SD increase in SHBG were estimated with logistic regression adjusted for potentially confounding factors, including age, bone mineral density, and other sex hormones. Higher SHBG was associated with a greater likelihood of prevalent vertebral fractures (OR: 1.38 per SD increase, 95% CI: 1.11, 1.72). Total estradiol analyzed as a continuous variable was not associated with prevalent vertebral fractures (OR per SD decrease: 0.86, 95% CI: 0.68 to 1.10). Men with total estradiol values ≤17pg/ml had a borderline higher likelihood of prevalent fract...Continue Reading
References
Sep 1, 1989·The Journal of Clinical Endocrinology and Metabolism·J J StĕpánD J Baylink
Aug 1, 1994·European Journal of Epidemiology·M PahorP Carbonin
Feb 1, 1993·Journal of Clinical Epidemiology·R A WashburnC A Janney
Jan 14, 2000·The Journal of Clinical Endocrinology and Metabolism·E Barrett-ConnorD J Sartoris
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Hermien W Goderie-PlompHuibert A P Pols
Aug 9, 2005·Contemporary Clinical Trials·Eric OrwollKatie Stone
Aug 9, 2005·Contemporary Clinical Trials·Janet Babich BlankRomelia Ramírez Delay
Dec 31, 2005·Clinical Chemistry·Frank GitonJean-Pierre Raynaud
May 3, 2006·The American Journal of Medicine·Shreyasee AminDouglas P Kiel
Jul 5, 2007·European Journal of Endocrinology·Ashild BjørneremBjørn Straume
Feb 28, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Peggy Mannen CawthonUNKNOWN Osteoporotic Fractures in Men (MrOS) Research Group
Sep 27, 2008·Bone·S P TuckR M Francis
May 8, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Peggy M CawthonUNKNOWN Osteoporotic Fractures in Men (MrOS) Research Group
Jul 9, 2009·The Journal of Clinical Endocrinology and Metabolism·Erin S LeBlancUNKNOWN Osteoporotic Fractures in Men Study Group
Aug 25, 2009·Molecular and Cellular Endocrinology·William RosnerNicholas A Romas
Sep 10, 2009·The Journal of Clinical Endocrinology and Metabolism·Peggy M CawthonUNKNOWN Osteoporotic Fractures in Men (MrOS) Research Group
Apr 22, 2010·Annals of Clinical Biochemistry·Brian L EglestonJoanne F Dorgan
Jun 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Shalender BhasinUNKNOWN Task Force, Endocrine Society
Jun 18, 2010·The Journal of Clinical Endocrinology and Metabolism·Jane A CauleyUNKNOWN Osteoporotic Fractures in Men Study (MrOS) Research Group
Jul 5, 2011·Bone·Abdellah El MaghraouiImad Ghozlani
Jun 8, 2012·The Journal of Clinical Endocrinology and Metabolism·Nelson B WattsUNKNOWN Endocrine Society
Jul 9, 2014·Bone·Peggy M CawthonUNKNOWN Osteoporotic Fractures in Men (MrOS) Research Group
Jul 23, 2014·Nature Reviews. Endocrinology·Michaël R Laurent, Dirk Vanderschueren
Jan 4, 2015·Steroids·Jane A Cauley
Mar 5, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Benjumin HsuDavid J Handelsman
Jun 18, 2015·Journal of Injury & Violence Research·Hosein KarimAlireza Ahmadi
Sep 24, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Liesbeth VandenputClaes Ohlsson
Citations
Apr 27, 2016·The Journal of Endocrinology·Geoffrey L Hammond
Oct 19, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eric S OrwollUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Research Group
Nov 11, 2016·Virulence·Maria Chiara Decaroli, Vincenzo Rochira
Mar 10, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Claes OhlssonLiesbeth Vandenput
Mar 21, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Carrie M NielsonUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Research Group
Nov 4, 2016·Physiological Reviews·Maria AlmeidaStavros C Manolagas
Mar 11, 2020·The Journal of Clinical Endocrinology and Metabolism·Bu B YeapLeon Flicker
Mar 23, 2018·Experimental and Therapeutic Medicine·Yu Zhao, Hongqi Zhang
Apr 19, 2017·Medicina·Beat KnechtleChristian B Baerlocher
Jun 12, 2018·Andrology·G DefeudisA M Isidori
Jul 3, 2018·BMC Musculoskeletal Disorders·Lei FengJin-Ming Shen
Jun 15, 2020·Skeletal Radiology·Justin T StowellRupert O Stanborough
Jul 26, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K HidayatB-M Shi
Nov 4, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gina N WoodsUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Research Group
Jul 2, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Benjumin HsuDavid J Handelsman
Mar 20, 2019·Endocrine Reviews·Jean-Marc KaufmanIlpo Tapani Huhtaniemi
Aug 28, 2020·Frontiers in Medicine·Yinwang ZhangJie Chen
Nov 23, 2016·Journal of Bone and Mineral Metabolism·Hye-Jung KimJi-Hee Haam
Dec 3, 2020·Pharmaceutical Biology·Hongjie WangSiyun Niu
Feb 9, 2021·JBMR Plus·Daniel D Bikle
Apr 7, 2021·Aging Clinical and Experimental Research·Jean-Marc Kaufman
May 16, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B HanuschH K Datta