Sex is associated with differences in gut microbial composition and function in hepatic encephalopathy.

Journal of Hepatology
Krishnakant SabooJasmohan S Bajaj

Abstract

Altered microbiota can affect the gut-liver-brain axis in cirrhosis and hepatic encephalopathy (HE), but the impact of sex on these changes is unclear. We aimed to determine differences in fecal microbiota composition/functionality between men and women with cirrhosis and HE on differing treatments. Cross-sectional stool microbiome composition (16s rRNA sequencing) and microbial functional analyses were performed in men and women with cirrhosis, and controls. Patients with HE on rifaximin+lactulose (HE-Rif), patients with HE on lactulose only (HE-Lac) and those with cirrhosis without HE (No-HE) were compared to controls using random forest classifier. Men and women were also compared. A total of 761 individuals were included, 619 with cirrhosis (466 men, 153 women) and 142 controls (92 men, 50 women). Men were older and more frequently used proton pump inhibitors (PPIs), but model for end-stage liver disease score, No-HE (n = 319), HE-lac (n = 130) and HE-Rif (n = 170) proportions were similar. PPI/age-adjusted AUC of differentiation between controls vs. all cirrhosis, and controls vs. No-HE were higher within women than men, but the adjusted AUC for No-HE vs. HE-Rif was higher in men. Control vs. HE-Rif differentiation was sim...Continue Reading

References

Aug 1, 1990·Journal of Clinical Gastroenterology·O RiggioL Capocaccia
May 1, 1973·Metabolism: Clinical and Experimental·A L SouthrenW S Rosenthal
Apr 11, 2009·PLoS Computational Biology·James Robert WhiteMihai Pop
Mar 26, 2010·The New England Journal of Medicine·Nathan M BassWilliam P Forbes
May 31, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Maria StepanovaZobair M Younossi
Jul 17, 2012·BMC Bioinformatics·Stacey J WinhamJoanna M Biernacka
Aug 27, 2013·Immunity·Leonid YurkovetskiyAlexander V Chervonsky
Mar 8, 2014·World Journal of Gastroenterology : WJG·Marilena DurazzoSimona Bo
Jul 10, 2014·Gut Microbes·Janet G M MarkleJayne S Danska
Jul 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hendrik VilstrupPhilip Wong
Dec 9, 2015·The American Journal of Gastroenterology·Sanath AllampatiJasmohan S Bajaj
Feb 3, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Eldin JašarevićTracy L Bale
Mar 1, 2016·Frontiers in Microbiology·David Ríos-CoviánNuria Salazar
Oct 5, 2016·JCI Insight·Ta-Chiang LiuNita H Salzman
May 21, 2017·Journal of Hepatology·Reiner WiestRajiv Jalan
Jul 18, 2017·Frontiers in Immunology·Floris FransenPaul de Vos
Mar 21, 2018·Nature·Lisa MaierAthanasios Typas
May 26, 2018·Nature Reviews. Microbiology·Rob KnightPieter C Dorrestein
Jun 12, 2018·Molecular Metabolism·Tzu-Wen L CrossFederico E Rey
Aug 14, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Chathur Acharya, Jasmohan S Bajaj
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Grace Hatton, Debbie L Shawcross
Mar 29, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Mingliang JinJuan G Abraldes
Mar 30, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Amedeo LonardoAyako Suzuki
Nov 7, 2019·American Journal of Physiology. Endocrinology and Metabolism·Hannah ColldénClaes Ohlsson
Nov 30, 2019·Biology of Sex Differences·Taylor PhelpsPamela Harvey
Feb 1, 2020·Journal of Hepatology·Jasmohan S Bajaj, Alexander Khoruts
Mar 25, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jasmohan S BajajHugo E Vargas

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.