Sex Matters: Male Hamsters Are More Susceptible to Lethal Infection with Lower Doses of Pathogenic Leptospira than Female Hamsters

Infection and Immunity
Charles K GomesMaria Gomes-Solecki

Abstract

A somewhat contradictory published body of evidence suggests that sex impacts severity outcomes of human leptospirosis. In this study, we used an acute animal model of disease to analyze leptospirosis in male and female hamsters infected side by side with low but increasing doses of Leptospira interrogans serovar Copenhageni. We found that male hamsters were considerably more susceptible to leptospirosis, given that only 6.3% survived infection, whereas 68.7% of the females survived the same infection doses. In contrast to the females, male hamsters had high burdens of L. interrogans in kidney and high histopathological scores after exposure to low infection doses (∼103 bacteria). In hamsters infected with higher doses of L. interrogans (∼104 bacteria), differences in pathogen burdens as well as cytokine and fibrosis transcript levels in kidney were not distinct between sexes. Our results indicate that male hamsters infected with L. interrogans are more susceptible to severe leptospirosis after exposure to lower infectious doses than females.

References

May 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·C T VanP Perolat
Apr 9, 2001·Clinical Microbiology Reviews·P N Levett
May 29, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juliette MorganUNKNOWN Leptospirosis Working Group
Feb 13, 2004·Epidemiology and Infection·C B Leal-CastellanosJ Escobedo-de la Peñal
Apr 28, 2006·Tropical Medicine & International Health : TM & IH·Khoa T D ThaiPeter J de Vries
Apr 5, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andreas JansenIrene Schöneberg
Jul 17, 2007·PLoS Pathogens·Paula RistowMathieu Picardeau
Aug 30, 2008·Nature Reviews. Immunology·Eleanor N Fish
Aug 29, 2012·Infection and Immunity·Azad EshghiCaroline E Cameron
Apr 30, 2013·Emerging Infectious Diseases·Marga G A GorisRudy A Hartskeerl
May 3, 2013·PloS One·Felipe Guerra-Silveira, Fernando Abad-Franch
Dec 25, 2013·Infection and Immunity·Amy M KingGerald L Murray
Feb 1, 2014·Nature·Francis S Collins, Lawrence A Tabak
May 17, 2014·Nature·Janine A Clayton, Francis S Collins
Jul 31, 2014·Emerging Infectious Diseases·Rita M TraxlerMarta A Guerra
Nov 13, 2014·Current Topics in Microbiology and Immunology·David A Haake, Paul N Levett
Sep 18, 2015·PLoS Neglected Tropical Diseases·Federico CostaAlbert I Ko
Sep 30, 2015·Infection and Immunity·Luciana RicherMaria Gomes-Solecki
Feb 20, 2016·PLoS Pathogens·Landon G vom Steeg, Sabra L Klein
Mar 9, 2017·Frontiers in Immunology·Maria Gomes-SoleckiCatherine Werts

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