Sex modifies genetic effects on residual variance in urinary calcium excretion in rat (Rattus norvegicus).

Genetics
Guy M L PerrySteven J Scheinman

Abstract

Conventional genetics assumes common variance among alleles or genetic groups. However, evidence from vertebrate and invertebrate models suggests that residual genotypic variance may itself be under partial genetic control. Such a phenomenon would have great significance: high-variability alleles might confound the detection of "classically" acting genes or scatter predicted evolutionary outcomes among unpredicted trajectories. Of the few works on this phenomenon, many implicate sex in some aspect of its control. We found that female genetic hypercalciuric stone-forming (GHS) rats (Rattus norvegicus) had higher coefficients of variation (CVs) for urinary calcium (CV = 0.14) than GHS males (CV = 0.06), and the reverse in normocalciuric Wistar-Kyoto rats (WKY) (CV(♂) = 0.14; CV(♀) = 0.09), suggesting sex-by-genotype interaction on residual variance. We therefore investigated the effect of sex on absolute-transformed residuals in urinary calcium in an F(2) GHS × WKY mapping cohort. Absolute residuals were associated with genotype at two microsatellites, D3Rat46 (RNO3, 33.9 Mb) and D4Mgh1 (RNO4, 84.8 MB) at Bonferroni thresholds across the entire cohort, and with the microsatellites D3Rat46, D9Mgh2 (RNO9, 84.4 Mb), and D12Rat25 (RN...Continue Reading

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Citations

Jan 1, 2012·Nephron. Physiology·Guy M L PerryJohn R Asplin
Sep 23, 2014·Trends in Genetics : TIG·William P GilksEdward H Morrow
Jan 25, 2013·American Journal of Physiology. Renal Physiology·Kevin K FrickDavid A Bushinsky
Apr 5, 2018·PloS One·Dalton ConleyMark L Siegal
Feb 28, 2014·American Journal of Physiology. Renal Physiology·Kevin K FrickDavid A Bushinsky
Aug 9, 2013·American Journal of Physiology. Renal Physiology·Kevin K FrickDavid A Bushinsky

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