Sex related differences in platelet TxA2 generation

Prostaglandins, Leukotrienes, and Essential Fatty Acids
S PintoR Abbate

Abstract

Platelet lipid composition, c arachidonic acid (AA) metabolism by platelets (stimulated with thrombin), serum thromboxane (Tx)B2 production and plasma lipid composition were investigated in 53 healthy females (18-45 years) and 65 males (19-45 years) with similar dietary habits. In males, serum TxB2 production and cholesterol platelet membrane levels were found significantly higher (p less than 0.001 and p less than 0.05) than in females. No differences were observed between the two groups in the AA conversion through cyclo-oxygenase and lipoxygenase pathways or in the platelet phospholipid fatty acid composition. These findings indicate that in males the platelet proaggregatory capacity is greater than in females and the higher platelet TxB2 production does not depend on a larger AA availability or on enzyme activation for its conversion. The increased TxB2 production may be, at least in part, induced by functional differences such as a different membrane cholesterol content inducing, in its turn, an increased microviscosity and/or higher number of platelet receptors for thrombin.

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Citations

Nov 9, 2012·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Peter BobbertUrsula Rauch
Mar 2, 2011·Molecular Aspects of Medicine·Maria MarinoFlavia Franconi
Jun 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S I MyersY Meng
Jan 31, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Paolo Di GiosiaAlbert Ferro
Mar 23, 2017·European Heart Journal. Cardiovascular Pharmacotherapy·J TamargoS Agewall
Sep 20, 2006·Circulation·Karen P AlexanderUNKNOWN CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of th
Jul 24, 2013·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Mauro Giovanni Carta

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