Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: The Hokkaido study

Environment International
Chihiro MiyashitaReiko Kishi

Abstract

Prenatal exposure to dioxin-like compounds (DLCs) irreversibly affects fetal reproductive and steroid hormone synthesis. This study aimed to assess the relationships between maternal DLCs and cord blood reproductive and steroid hormones. Participants in this study were pregnant women who enrolled in the Sapporo Cohort of the Hokkaido Study between 2002 and 2005. We quantified 29 DLCs during the 2nd and 3rd trimesters in maternal blood. Additionally, we measured the concentrations of progesterone, estradiol (E2), testosterone (T), androstenedione, dehydroepiandrosterone (DHEA), cortisol, cortisone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, inhibin B, and insulin-like factor-3 (INSL3) in cord blood samples. Data from 183 mother-child pairs were analyzed. We observed sex-dependent associations of DLCs on T/E2 ratios, DHEA, cortisol, cortisone, adrenal androgen/glucocorticoid (AA/GC: sum of DHEA and androstenedione)/(sum of cortisol and cortisone) ratios and SHBG. An increase in maternal DLCs related to decreased T/E2 ratios and SHBG and inhibin B levels, and increased AA/GC ratios and FSH and DHEA levels in male cord blood samples. However, an increase in maternal...Continue Reading

Citations

Oct 3, 2018·Nihon eiseigaku zasshi. Japanese journal of hygiene·Atsuko ArakiReiko Kishi
Oct 16, 2019·Frontiers in Endocrinology·Steven M HarrisonLinda A Baker
May 6, 2020·Environmental Science and Pollution Research International·Li Li ShiHao Feng
May 24, 2021·Environmental Health and Preventive Medicine·Reiko KishiUNKNOWN members of The Hokkaido Study on Environment and Children’s Health
Jun 3, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Takahiko Mitsui

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