Abstract
This study examined sex-related differences in use and outcomes of continuous-flow left ventricular assist devices (CF-LVADs) among individuals awaiting heart transplantation using the United Network for Organ Sharing registry. Advanced therapies for heart failure including CF-LVADs remain underused in women. There have been contradictory results regarding sex-specific outcomes. Many studies have been limited by small sample sizes or included pulsatile-flow devices. De-identified patient-level data were obtained from the United Network for Organ Sharing database. The database was queried to identify adult patients (≥18 years of age) who required mechanical circulatory support with HeartWare HVAD (Medtronic, Minneapolis, Minnesota), HeartMate II (Abbott, Lake Bluff, Illinois), or HeartMate 3 (Abbott) as bridge to heart transplantation between 2008 and 2018. Each patient was assigned a propensity score. The primary outcomes of interest were rates of transplantation and death. A total of 13,305 patients (2,771 women, 20.8%) received support with CF-LVAD in the study period. There were significant sex disparities in CF-LVAD use in listed patients (29.9% men vs. 18.9% women in 2017). Female patients receiving CF-LVAD support had low...Continue Reading
Citations
Nov 28, 2019·Expert Review of Medical Devices·Silvia MarianiGünes Dogan
Jul 7, 2020·ESC Heart Failure·Alexis Kofi OkohMark J Russo
Apr 19, 2020·Journal of Cataract and Refractive Surgery·Cassandra C BrooksTerry Kim
Jul 22, 2020·JAMA Network Open·Khadijah BreathettNancy K Sweitzer
Aug 3, 2020·Journal of Cardiac Surgery·Teruhiko ImamuraValluvan Jeevanandam
Feb 6, 2020·Intensive Care Medicine·Sakir AkinUNKNOWN EUROMACS investigators
Oct 11, 2019·Circulation. Heart Failure·Yasbanoo MoayediKiran K Khush
Feb 20, 2020·Clinical Transplantation·Rebecca S SteinbergAlanna A Morris
Sep 14, 2019·Circulation. Heart Failure·Aditya A JoshiAmresh Raina
Jan 26, 2021·The Journal of Thoracic and Cardiovascular Surgery·Amy S WangKoji Takeda
Jan 23, 2021·ESC Heart Failure·Moritz Benjamin ImmohrRené Schramm
Jan 26, 2021·Circulation. Heart Failure·Ersilia M DeFilippisRon Blankstein
Sep 2, 2020·Journal of cardiology·Sandeep DayanandShuchita Gupta
Jan 1, 2021·The Canadian Journal of Cardiology·Kristen SullivanHarriette G C Van Spall
Mar 1, 2021·Journal of Cardiac Failure·Matthew H GonzalezEmer Joyce
Mar 16, 2021·Frontiers in Cardiovascular Medicine·María Dolores García-CosíoJuan F Delgado
Mar 26, 2021·Journal of the American Heart Association·Aditi NayakAlanna A Morris
Oct 17, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Aditi NayakAlanna A Morris
Jul 30, 2021·Heart & Lung : the Journal of Critical Care·Sarah LöchelHeike Spaderna
Aug 20, 2021·Journal of Cardiovascular Electrophysiology·Angeliki DarmaArash Arya
Sep 29, 2021·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Yuji TominagaShigeru Miyagawa
Aug 15, 2021·The Annals of Thoracic Surgery·Leora T YarboroJames D Bergin
Jun 23, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Seraina Anne DualJennifer Cowger