Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

Frontiers in Neuroendocrinology
Claudia B SpäniLinda J Van Eldik

Abstract

Traumatic brain injury (TBI) has historically been viewed as a primarily male problem, since men are more likely to experience a TBI because of more frequent participation in activities that increase risk of head injuries. This male bias is also reflected in preclinical research where mostly male animals have been used in basic and translational science. However, with an aging population in which TBI incidence is increasingly sex-independent due to falls, and increasing female participation in high-risk activities, the attention to potential sex differences in TBI responses and outcomes will become more important. These considerations are especially relevant in designing preclinical animal models of TBI that are more predictive of human responses and outcomes. This review characterizes sex differences following TBI with a special emphasis on the contribution of the female sex hormones, progesterone and estrogen, to these differences. This information is potentially important in developing and customizing TBI treatments.

Citations

Feb 23, 2019·Journal of Neurotrauma·Raeesa GupteJanna Harris
Feb 23, 2019·Journal of Neurochemistry·Christina GölzMichael K E Schäfer
Feb 1, 2020·Reviews in the Neurosciences·Haym Benaroya
Dec 19, 2019·Cephalalgia : an International Journal of Headache·Dan LevyRuth Defrin
Jun 11, 2019·Frontiers in Neurology·Laura B TuckerJoseph T McCabe
Jan 4, 2019·Journal of Molecular Neuroscience : MN·Joanna A RuszkiewiczMichael Aschner
Aug 28, 2020·Frontiers in Neurology·Andrew N StewartMelinda E Wilson
Dec 12, 2018·Acta Neuropathologica·Maria Cristina Morganti-KossmannJenna M Ziebell
Jul 30, 2020·International Journal of Molecular Sciences·Rachida Guennoun
Aug 26, 2020·Journal of Neurotrauma·Ana MikolićUNKNOWN CENTER-TBI Participants and Investigators
Sep 27, 2020·Journal of Neurotrauma·Jahnavi MundluruCorinne E Fischer
Oct 23, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Zaynab ShakkourFiras Kobeissy
Apr 10, 2020·Brain, Behavior, and Immunity·Meng-Xian PanZe-Fen Wang
Dec 29, 2020·Journal of Advanced Research·Abdullah Al MamunJian Xiao
Oct 27, 2020·Frontiers in Neurology·Joseph T McCabe, Laura B Tucker
Nov 10, 2020·The Journal of Head Trauma Rehabilitation·Angela PhillipsMaheen Adamson
Dec 31, 2020·International Journal of Molecular Sciences·Erzsébet KövesdiIstván M Abrahám
Oct 31, 2020·Journal of Neuroinflammation·Eric EyolfsonAlexander W Lohman
Mar 5, 2019·Experimental Neurology·Sheryl E ArambulaCourtney L Robertson
Mar 17, 2019·Experimental Neurology·Ramona E von LedenMichael H Donovan
Jul 6, 2021·Neurotrauma Reports·Rachel K RoweTheresa Currier Thomas
Jul 3, 2021·International Journal of Molecular Sciences·Shotaro Michinaga, Yutaka Koyama
Aug 13, 2021·Neural Regeneration Research·Theresa Currier ThomasGokul Krishna
Oct 8, 2021·Journal of Neurotrauma·Ana MikolicUNKNOWN Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Participants and Investigat

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.