Sex-related variations in bone microstructure of rabbits intramuscularly exposed to patulin

Acta Veterinaria Scandinavica
Hana DuranovaM Martiniaková

Abstract

Patulin, a toxic mold metabolite, has been found as natural contaminant of processed fruits, most notably apples, apple juices and other apple-based products. A number of adverse health effects in humans and animals are associated with patulin intoxication. The current study was performed to analyse possible toxic effects of patulin on femoral bone microstructure in adult rabbits in detail. Fourteen clinically healthy four-month-old rabbits of both sexes (6 males and 8 females) were included in the study. Animals from the experimental groups (group E♂, n = 3; group E♀, n = 4) were injected intramuscularly with patulin at dose 10 μg/kg body weight two times a week for 28 days. The dose of patulin was estimated based on the maximum permitted level of patulin for apple products intended for infants and young children. Three males and four females without patulin administration served as controls (groups C♂ and C♀). Cortical bone thickness and qualitative and quantitative histological characteristics of compact bone tissue were investigated. Intramuscular applications of patulin significantly increased the thickness of cortical bone in both sexes of rabbits. In patulin-exposed males, an absence of primary vascular longitudinal bone...Continue Reading

References

Jan 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G J SpeijersF X van Leeuwen
Mar 1, 1983·Applied and Environmental Microbiology·D V MauriceN J Rehrer
Jul 1, 1980·Applied and Environmental Microbiology·W E HuffA Ciegler
Mar 1, 1993·Journal of Dairy Science·R P Sharma
Jul 15, 2000·Journal of Chromatography. a·G S Shephard, N L Leggott
Sep 25, 2001·Toxicology·H S Hussein, J M Brasel
Jul 15, 2003·Clinical Microbiology Reviews·J W Bennett, M Klich
Mar 1, 1961·British Journal of Cancer·F DICKENS, H E JONES
Sep 1, 1962·The British Journal of Radiology·P VIRTAMA, A TELKKA
Mar 30, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Güldeniz Selmanoglu, E Arzu Koçkaya
Sep 6, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A H HeussnerE O'Brien
Mar 2, 2006·Journal of Agricultural and Food Chemistry·Yumiko IwahashiHitoshi Iwahashi
Aug 15, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Güldeniz Selmanoğlu
Sep 28, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Pawel SzulcPierre D Delmas
Dec 21, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E Seeman
Mar 6, 2007·European Cells & Materials·A I PearceS G Pearce
Sep 14, 2007·Food Additives and Contaminants·L González-OsnayaJ Mañes
Dec 21, 2007·Journal of Bone and Mineral Metabolism·Ego Seeman
Jun 5, 2008·Acta Veterinaria Scandinavica·Monika MartiniakováPeter Chrenek
Oct 25, 2008·Chemical Society Reviews·Gordon Seymour Shephard
Nov 11, 2008·Toxicology Letters·Ting-Shuan WuBiing-Hui Liu
Dec 4, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Steven BoonenPierre D Delmas
Dec 17, 2009·Acta Veterinaria Scandinavica·Monika MartiniakováPeter Chrenek
Jan 12, 2010·Arhiv za higijenu rada i toksikologiju·Evrim Arzu KoçkayaNursel Gül
Sep 3, 2010·The Journal of Endocrinology·Filip CallewaertDirk Vanderschueren
Mar 16, 2011·Journal of Biomedicine & Biotechnology·Offie P SoldinDonald R Mattison
Apr 1, 2010·Toxins·Olivier PuelIsabelle P Oswald
Jan 24, 2012·International Journal of Food Microbiology·Katleen BaertBruno De Meulenaer
Feb 4, 2012·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Anna Del PreteCarmelina Loguercio
Mar 20, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nina Glaser, Helga Stopper
Jan 1, 2005·Comprehensive Reviews in Food Science and Food Safety·Matthew M MoakeRandy W Worobo

❮ Previous
Next ❯

Citations

Nov 28, 2019·Animal Models and Experimental Medicine·Aline Schafrum MacedoCassio Ricardo Auada Ferrigno
Feb 13, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jiahui HanXiaoli Peng
Jul 7, 2018·Journal of Veterinary Research·Ewa TomaszewskaMonika Hułas-Stasiak

❮ Previous
Next ❯

Software Mentioned

Motic Images Plus

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.