Sex specific adaptations in placental biometry of overweight and obese women

Placenta
Chiara MandòIrene Cetin

Abstract

Placental biometry at birth has been shown to predict chronic disease in later life. We hypothesized that maternal overweight/obesity, a state of low-grade inflammation and risk factor for adverse pregnancy outcome, could negatively influence placental development and that differences would be sex-specific. 696 women (537 normal-weight, NW; 112 overweight, OW; 47 obese, OB) with singleton uncomplicated pregnancies were prospectively enrolled at term delivery. Gestational age, maternal (age, height, pre-pregnancy BMI, gestational weight gain -GWG, hemoglobin, hematocrit and glycemia), fetal (weight, length, ponderal index, cranial circumference) and placental (weight, diameters) data were collected. Placental area, thickness and efficiency (fetal/placental weight ratio, F/P) were calculated. GWG was within standard recommendations in OB, while OW exceeded it. Placental weight was significantly higher in OW versus NW, but not in OB, leading to significantly higher placental thickness and lower F/P in this group. In the total population, a significant interaction effect between maternal BMI and fetal sex on placental weight and efficiency was found. Indeed, differences in placental parameters were present only in female offspring....Continue Reading

Associated Clinical Trials

Jul 12, 2017·Fátima Lúcia de Carvalho Sardinha

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Citations

Jun 20, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·G M AnelliC Mandò
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May 10, 2019·Frontiers in Pediatrics·Gaia Maria AnelliIrene Cetin
Sep 7, 2018·Oxidative Medicine and Cellular Longevity·Chiara MandòIrene Cetin
Jul 5, 2017·Frontiers in Pediatrics·Mohammed Al-Qaraghouli, Yu Ming Victor Fang
Sep 12, 2020·Biology of Sex Differences·Nihal A SalemUNKNOWN Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD)
Feb 13, 2021·International Journal of Molecular Sciences·Francesca ParisiIrene Cetin
Nov 1, 2020·International Journal of Molecular Sciences·Simon KecksteinTheresa M Kolben
Jan 1, 2021·International Journal of Molecular Sciences·Sophida PhuthongSilvia M Arribas
Nov 14, 2020·Journal of Developmental Origins of Health and Disease·Matthew BucherAlina Maloyan
Nov 7, 2020·Scientific Reports·Meng Yuan TianHong Zhuan Tan
Mar 13, 2021·Reproductive Sciences·Marta ZambonIrene Cetin
Oct 27, 2021·Reproductive Sciences·Julian K Christians
Jan 16, 2022·Clinical Reviews in Allergy & Immunology·Alice ZavattaIrene Cetin

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