Sex-specific assembly of a dosage compensation complex on the nematode X chromosome

Science
P T ChuangB J Meyer

Abstract

In nematodes, flies, and mammals, dosage compensation equalizes X-chromosome gene expression between the sexes through chromosome-wide regulatory mechanisms that function in one sex to adjust the levels of X-linked transcripts. Here, a dosage compensation complex was identified in the nematode Caenorhabditis elegans that reduces transcript levels from the two X chromosomes in hermaphrodites. This complex contains at least four proteins, including products of the dosage compensation genes dpy-26 and dpy-27. Specific localization of the complex to the hermaphrodite X chromosomes is conferred by XX-specific regulatory genes that coordinately control both sex determination and dosage compensation.

References

Dec 8, 1995·Science·R L Kelley, M I Kuroda
Jun 1, 1995·Current Opinion in Cell Biology·T HiranoJ R Swedlow
Sep 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N SaitohW C Earnshaw
Jan 1, 1996·Annual Review of Genetics·T W Cline, B J Meyer

❮ Previous
Next ❯

Citations

Mar 25, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Sevinc Ercan, Jason D Lieb
Oct 6, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Györgyi CsankovszkiKarishma S Collette
Sep 2, 1998·Trends in Genetics : TIG·J E Haber
Jun 26, 1998·Current Opinion in Cell Biology·T Hirano
Jun 4, 1998·Current Opinion in Genetics & Development·R JessbergerS M Gasser
Dec 17, 1998·Trends in Cell Biology·A V Strunnikov
Feb 1, 2000·Trends in Cell Biology·V H Meller
Jul 1, 1997·Nature Genetics·R Brent
Oct 3, 2002·Nature Reviews. Molecular Cell Biology·Rolf Jessberger
Jul 31, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yoshimi NiwaMasahiro Ishiura
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Joydeep DeVijay Kumar Sharma
Jun 22, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christopher J Reaume, Marla B Sokolowski
Oct 15, 2010·Cold Spring Harbor Perspectives in Biology·Jennifer C Chow, Edith Heard
Jun 6, 1998·Genes & Development·R A BrittonA D Grossman
Apr 9, 2002·Genes & Development·Diana S ChuBarbara J Meyer
Aug 25, 2005·Cold Spring Harbor Symposia on Quantitative Biology·B J MeyerE Ralston
Sep 21, 2001·Molecular and Cellular Biology·E RevenkovaR Jessberger
Jul 27, 2002·Annual Review of Cell and Developmental Biology·Justin Goodrich, Susan Tweedie
Apr 13, 2000·Annual Review of Entomology·J M Giebultowicz
Feb 3, 1999·Annual Review of Genetics·J E Haber
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·Y Z GuC A Bradfield
Nov 8, 2005·Genetics·Neville CobbeMargarete M S Heck
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·M DoiY Fukada
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·A A PeixotoC P Kyriacou
Dec 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ben H CollinsCharalambos P Kyriacou
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·J C ConnellyD R Leach
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·E S MaywoodM H Hastings
Feb 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Wolfgang BachleitnerCharlotte Helfrich-Förster
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·K P WrightC A Czeisler
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·I F EmeryK K Siwicki
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·C J Weitz
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y D ZhouS L McKnight
Nov 23, 2000·Current Opinion in Genetics & Development·A Pannuti, J C Lucchesi
Jun 4, 1998·Current Opinion in Genetics & Development·J C Lucchesi
Mar 31, 2005·Current Opinion in Genetics & Development·Dmitri A Nusinow, Barbara Panning
May 17, 2000·The Journal of Cell Biology·L FreemanA Strunnikov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.