Sex-Specific Asthma Phenotypes, Inflammatory Patterns, and Asthma Control in a Cluster Analysis

The Journal of Allergy and Clinical Immunology. in Practice
Han-Pin HsiaoTsu-Nai Wang

Abstract

Asthma is a heterogeneous disease with complex mechanisms and involves many risk factors and in vivo cellular molecules. It is notable that sex differences may have a potential effect on asthma phenotype. To identify sex-specific phenotypes and health outcomes of asthma. We conducted the Taiwanese Adult Asthma Cohorts study to enroll female (n = 421) and male (n = 299) adult patients with stable asthma. Eight variables were selected by a factor analysis. We further performed a 2-step sensitivity cluster analysis to classify asthma clusters. The risks of asthma-related outcomes among the clusters were assessed using simple logistic regressions. Three different clusters were identified in males and females. In the female clusters, atopy/eosinophil-predominant (cluster 2), and obesity/neutrophil-predominant pattern (cluster 3) had more than a 2-fold risk of asthma exacerbations (odds ratio, 2.51; 95% CI, 1.12-5.59 and odds ratio, 2.22; 95% CI, 1.01-4.93). In the male clusters, current smoker/neutrophilic atopic cluster (cluster 5) and ex-smoker/eosinophil-predominant or mixed inflammatory pattern (cluster 6) also had a higher risk of asthma exacerbations. This study identified heterogeneous characteristics between sexes. In female...Continue Reading

Citations

Jul 17, 2019·Allergy·Eric SzeParameswaran Nair
May 29, 2020·JMIR Medical Informatics·Elsie HorneAthanasios Tsanas
Feb 12, 2021·Molecular Diagnosis & Therapy·Mario CazzolaMaria Gabriella Matera
Sep 29, 2019·Revue des maladies respiratoires·J TaytardG Aubertin
Apr 28, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Rodrigo C BorgesJosé R Jardim
May 1, 2021·Diagnostics·Francisco CunhaJoão A Fonseca
Sep 10, 2019·Respiratory Medicine·Tunn Ren TayMariko S Koh
Dec 23, 2019·International Archives of Allergy and Immunology·Ana Carolina A F Sousa-SantosL Karla Arruda
Dec 19, 2021·Current Allergy and Asthma Reports·Varun Sharma, Douglas C Cowan
Jan 26, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Michael SchatzRobert S Zeiger

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