Sex-specific differences in the expression levels of estrogen receptor subtypes in colorectal cancer

Gender Medicine
Natascha C NüsslerMartin Kirschner

Abstract

Altered expression of estrogen receptors alpha and beta (ERalpha and ERbeta) has been hypothesized to play a role in carcinogenesis. However, little is known about the sex-specific differences of ER expression in colorectal cancer (CRC). This study examined ERalpha and ERbeta protein levels in male and female patients with CRC. Using Western blot analysis, the intensity of ERalpha and ERbeta protein levels was determined in tumor tissue and in corresponding normal colon mucosa from patients with CRC. All 64 white patients (33 men, mean [SEM] age 64.1 [13.1] years, age range 26-90 years; 31 women, mean age 68.5 [14.5] years, age range 39-91 years [4 were premenopausal at time of surgery]) expressed ERalpha and ERbeta protein in normal colon mucosa, and there were no significant differences between men and women. In tumor tissue, a significantly increased ERalpha protein level was observed in men (P = 0.02 vs normal tissue), whereas in women, the ERalpha level did not differ significantly between tumor and normal tissue. The level of ERbeta protein in CRC was significantly reduced in both men and women, but more so in men (P = 0.04 vs women). Furthermore, in men, the ERbeta level was significantly lower in poorly differentiated t...Continue Reading

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Citations

Jun 1, 2012·Archives of Toxicology·Katherine A Burns, Kenneth S Korach
Feb 3, 2012·International Journal of Colorectal Disease·Kazushige KawaiToshiaki Watanabe
Jan 16, 2013·International Journal of Colorectal Disease·Paul A Foster
Dec 29, 2015·Cancer Letters·Cecilia WilliamsJan-Åke Gustafsson
Apr 17, 2012·International Journal of Radiation Oncology, Biology, Physics·Daniela TraniAlbert J Fornace
Dec 15, 2015·Pathology, Research and Practice·Despoina GeorgiadouGeorge C Zografos
May 27, 2010·International Journal of Cancer. Journal International Du Cancer·Gwen MurphyMichael B Cook
Apr 12, 2011·Molecular Carcinogenesis·Elizabeth A RondiniJenifer I Fenton
Jul 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth J Folkerd, Mitch Dowsett
Apr 16, 2011·Molecular Endocrinology·Karin EdvardssonCecilia Williams
Jun 29, 2012·Oncology Letters·Jianjun WangChaoyang Xu
Sep 21, 2018·Frontiers in Oncology·Lígia A B M MendonçaCristiano M E Carvalho
Sep 15, 2015·European Journal of Gastroenterology & Hepatology·Yaron Niv
Aug 22, 2017·Digestive Diseases and Sciences·Pablo M LinaresMaría-Encarnación Fernández-Contreras
Apr 24, 2014·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Hee Man Kim, Hyun Soo Kim
Oct 23, 2019·Toxicological Research·Ji Yoon ShinAree Moon
Mar 11, 2020·International Journal of Molecular Sciences·Tze-An YuanFeng Liu-Smith
Nov 17, 2020·Frontiers in Physiology·Tsolmon ChuluunbaatarYasuhiro Kon
Jan 19, 2021·BioMed Research International·Hui ShengMinjie Mao
Jul 18, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Angela E DeanSayeepriyadarshini Anakk

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