Sex-specific differences in the occurrence of Fusobacterium nucleatum subspecies and Fusobacterium periodonticum in the oral cavity

Oncotarget
Karsten HenneHans-Peter Horz

Abstract

The periodontitis-associated species Fusobacterium nucleatum (FN) has been implicated in several extra-oral diseases, including preterm birth and colorectal cancer. Due to its genetic and phenotypic heterogeneity, FN is classified in four subspecies which may differ in their disease potential. Here we compared the prevalence of FN subspecies and the close relative F. periodonticum (FP) via 16S rRNA gene analysis in saliva from 100 healthy individuals (60 females, and 40 males) from eleven countries spanning five continents. By focusing on the most abundant sequence types (i.e. analysis of approximately ten clone sequences each) the average number of FN/FP subspecies per individual differed significantly between females and males, i.e. 2.93 versus 2.5, respectively (P = 0.043). FN subsp. fusiforme/vincentii was significantly more prevalent in females vs males, with 2.85 vs. 1.68 sequence reads per individual, respectively (P = 0.012). A significant age-related difference was observed in females but not in males, i.e. 2.6 subspecies on average in females ≤ 30 years vs. 3.2 in females > 30 (P = 0.0076). Given the link between FN and systemic disorders our findings highlight the need for microbial studies at the subspecies level to...Continue Reading

References

Dec 1, 1990·Oral Microbiology and Immunology·S E GharbiaM Haapasalo
Sep 1, 1983·Journal of Dental Research·J SlotsP A Mashimo
Apr 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E J GoldsteinS M Finegold
Jan 1, 1996·Clinical Microbiology Reviews·A I BolstadV Bakken
Mar 12, 1998·Journal of Clinical Periodontology·S S SocranskyR L Kent
Sep 2, 1998·Annals of Periodontology·G B Hill
Mar 29, 2008·Briefings in Bioinformatics·Kazutaka Katoh, Hiroyuki Toh
Apr 2, 2008·Internal Medicine·Takashi KajiyaChuwa Tei
May 15, 2008·Cancer Causes & Control : CCC·Mara S MeyerDominique S Michaud
Mar 3, 2009·Genome Research·Ivan NasidzeMark Stoneking
Sep 12, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mine TezalFrank A Scannapieco
Nov 10, 2009·Journal of Dentistry·Sarah G Fitzpatrick, Joseph Katz
May 27, 2010·International Journal of Cancer. Journal International Du Cancer·Gwen MurphyMichael B Cook
Jul 3, 2010·Journal of Periodontology·Harlan J Shiau, Mark A Reynolds
Oct 20, 2011·Genome Research·Mauro CastellarinRobert A Holt
Nov 10, 2011·Gut Microbes·Emma Allen-VercoeKris Chadee
Dec 18, 2012·Periodontology 2000·Angelo Mariotti, Michael Mawhinney
Jan 22, 2013·PloS One·Amber N McCoyTemitope O Keku
Apr 30, 2013·Journal of Dental Research·Y W Han, X Wang
Dec 11, 2013·Periodontology 2000·Harlan J ShiauMark A Reynolds
Jan 9, 2015·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Arif BashirBashir A Ganai
Dec 23, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jo L FreudenheimJean Wactawski-Wende
Jun 14, 2016·Journal of Periodontology·Xian-Tao ZengJoey S W Kwong
Sep 30, 2016·Journal of Oral Microbiology·Manosha PereraNewell W Johnson
Oct 21, 2016·Journal of Periodontology·Şivge KurganAlpdogan Kantarci
Nov 30, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kentaro NagaokaShigeru Kohno
Nov 30, 2016·International Journal of Molecular Sciences·Shan JiangEdward C M Lo
Mar 10, 2017·Current Medical Research and Opinion·Maria Luisa MartelliFrancesco Martelli
Oct 20, 2017·Journal of Gastroenterology and Hepatology·Toshiko FujiiJunko Tanaka

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Citations

May 15, 2019·Cancers·Christian KaltschmidtBarbara Kaltschmidt

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Methods Mentioned

BETA
PCR

Software Mentioned

MEGA
MAFFT ( Multiple Alignment using Fast Fourier Transform )
Vector NTI Advance
MAFFT

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