Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium

JACC. Heart Failure
Christina MagnussenBiomarCaRE Consortium

Abstract

This study investigates differences between women and men in heart failure (HF) risk and mortality. Sex differences in HF epidemiology are insufficiently understood. In 78,657 individuals (median 49.5 years of age; age range 24.1 to 98.7 years; 51.7% women) from community-based European studies (FINRISK, DanMONICA, Moli-sani, Northern Sweden) of the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium, the association between incident HF and mortality, the relationship of cardiovascular risk factors, prevalent cardiovascular diseases, biomarkers (C-reactive protein [CRP]; N-terminal pro-B-type natriuretic peptide [NT-proBNP]) with incident HF, and their attributable risks were tested in women vs. men. Over a median follow-up of 12.7 years, fewer HF cases were observed in women (n = 2,399 [5.9%]) than in men (n = 2,771 [7.3%]). HF incidence increased markedly after 60 years of age, initially with a more rapid increase in men, whereas incidence in women exceeded that of men after 85 years of age. HF onset substantially increased mortality risk in both sexes. Multivariable-adjusted Cox models showed the following sex differences for the association with incident HF: systolic blood pressure hazard ratio (H...Continue Reading

Citations

Apr 17, 2020·Journal of the American Heart Association·Amanda B PullenGanesh V Halade
Jun 3, 2020·European Journal of Heart Failure·Amy GroenewegenArno W Hoes
Mar 29, 2020·European Journal of Heart Failure·Navin SuthaharRudolf A de Boer
Jan 21, 2021·Frontiers in Cardiovascular Medicine·Germán CedielAntoni Bayes-Genis

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