Sex-Specific Genetically Predicted Iron Status in relation to 12 Vascular Diseases: A Mendelian Randomization Study in the UK Biobank.

BioMed Research International
Fangkun YangXiaojie Xie

Abstract

Iron overload has been implicated in the pathogenesis of varicose veins (VVs). However, the association of serum iron status with other vascular diseases (VDs) is not well understood, which might be a potential target for VD prevention. This study was aimed at investigating the causal associations between iron status and VDs using the Mendelian randomization (MR) method. A two-sample MR was designed to investigate whether iron status was associated with VDs, based on iron data from a published genome-wide association study meta-analysis of 48,972 subjects of European descent and VD data obtained from the UK Biobank, including 361,194 British subjects (167,020 males and 194,174 females). We further explored whether there was sex difference in the associations between genetically predicted iron status and VDs. The results demonstrated that iron status had a significant causal effect on VVs of lower extremities (P < 0.001) and a potential effect on coronary atherosclerosis (P < 0.05 for serum iron, ferritin, and transferrin saturation, respectively), but not on other VDs. Furthermore, higher iron status exerted a detrimental effect on VVs of lower extremities in both genders (P < 0.05) and a protective effect on male patients with...Continue Reading

References

Mar 1, 1994·Epidemiology·H I MorrisonD T Wigle
Jul 16, 1999·Vascular Medicine·L D Horwitz, E A Rosenthal
Apr 12, 2003·International Journal of Epidemiology·George Davey Smith, Shah Ebrahim
Oct 22, 2003·Circulation·Kathy K Griendling, Garret A FitzGerald
Nov 25, 2003·The Journal of Investigative Dermatology·Sim Yeoh-Ellerton, Michael C Stacey
Aug 17, 2005·Journal of Vascular Surgery·Paolo ZamboniDonato Gemmati
Sep 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Jay B Wish
Sep 22, 2007·Statistics in Medicine·Debbie A LawlorGeorge Davey Smith
Jul 9, 2008·Trends in Genetics : TIG·Tracey A Rouault, Wing Hang Tong
Mar 12, 2009·The Journal of Biological Chemistry·Kevin J WoollardShaun P Jackson
Apr 29, 2009·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Christina Nyström-RosanderNils-Gunnar Ilbäck
Jun 1, 2010·Immunity·Siamon Gordon, Fernando O Martinez
Feb 15, 2011·The Journal of Clinical Investigation·Anca SindrilaruKarin Scharffetter-Kochanek
Sep 10, 2011·Journal of the American College of Cardiology·Darlington O OkonkoPhilip A Poole-Wilson
Jun 12, 2013·PLoS Medicine·Irene PichlerCosetta Minelli
Oct 30, 2014·Nature Communications·Beben BenyaminJohn B Whitfield
Sep 30, 2015·Clinical and Experimental Medicine·Ekaterina A SokolovaMaxim L Filipenko
May 21, 2017·European Journal of Epidemiology·Stephen Burgess, Simon G Thompson
Jul 8, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Dipender GillCosetta Minelli
Jul 14, 2018·BMJ : British Medical Journal·Neil M DaviesGeorge Davey Smith
Dec 21, 2018·Stroke; a Journal of Cerebral Circulation·Dipender GillAbbas Dehghan

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
biopsy

Software Mentioned

MR
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.