Sex-specific lipid molecular signatures in obesity-associated metabolic dysfunctions revealed by lipidomic characterization in ob/ob mouse

Biology of Sex Differences
Marcela González-GranilloMarion Korach-André

Abstract

The response to overfeeding is sex dependent, and metabolic syndrome is more likely associated to obesity in men or postmenopausal women than in young fertile women. We hypothesized that obesity-induced metabolic syndrome is sex dependent due to a sex-specific regulation of the fatty acid (FA) synthesis pathways in liver and white adipose depots. We aimed to identify distinctive molecular signatures between sexes using a lipidomics approach to characterize lipid species in liver, perigonadal adipose tissue, and inguinal adipose tissue and correlate them to the physiopathological responses observed. Males had less total fat but lower subcutaneous on visceral fat ratio together with higher liver weight and higher liver and serum triglyceride (TG) levels. Males were insulin resistant compared to females. Fatty acid (FA) and TG profiles differed between sexes in both fat pads, with longer chain FAs and TGs in males compared to that in females. Remarkably, hepatic phospholipid composition was sex dependent with more abundant lipotoxic FAs in males than in females. This may contribute to the sexual dimorphism in response to obesity towards more metaflammation in males. Our work presents an exhaustive novel description of a sex-specif...Continue Reading

References

Dec 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·P U Dubuc
Oct 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·V Di Marzo
Nov 14, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·E Blaak
Jul 20, 2002·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Jillian CrollMarjorie Ireland
Mar 28, 2003·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·B L WajchenbergR F Santos
Mar 28, 2003·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C BélangerA Tchernof
Dec 29, 2004·Cardiovascular Research·Judith BrouilletteCéline Fiset
Feb 25, 2005·Lipids·James M NtambiAgnieszka Dobrzyn
Mar 30, 2005·The Journal of Nutrition·Bettina Mittendorfer
Sep 8, 2005·The Journal of Biological Chemistry·Zhaoyu LiDennis E Vance
Oct 28, 2005·The Journal of Nutrition·Werner G Bergen, Harry J Mersmann
Mar 29, 2006·Diabetes·Deborah J CleggStephen C Benoit
Apr 7, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·V Regitz-ZagrosekM O Weickert
Apr 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stephane GestaC Ronald Kahn
Aug 8, 2006·Biotechnology Journal·Undurti N Das
Oct 19, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A P Simopoulos
Oct 31, 2006·Journal of Diabetes and Its Complications·Hiroshi NotoPhilip Raskin
Apr 26, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mary ResseguieSteven H Zeisel
Jul 5, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Onpan CheungArun J Sanyal
Feb 23, 2008·Endocrinology·Annelie BrolinsonAnders Jacobsson
Mar 13, 2008·American Journal of Physiology. Endocrinology and Metabolism·Qian Gao, Tamas L Horvath
Oct 29, 2008·Seminars in Liver Disease·Onpan Cheung, Arun J Sanyal
Feb 4, 2009·The Journal of Clinical Investigation·Mohammed QatananiMitchell A Lazar
Dec 19, 2009·Progress in Lipid Research·Hervé GuillouAnders Jacobsson
Mar 4, 2010·Genome Biology·Mark D Robinson, Alicia Oshlack
Dec 17, 2011·Journal of Hepatology·Lars P BechmannAli Canbay
Jul 7, 2012·Journal of Cellular Physiology·M Luísa DóriaLuisa A Helguero
Jul 18, 2012·Biochemical and Biophysical Research Communications·P AntonsonJ-Å Gustafsson
Jun 14, 2013·Journal of Diabetes Research·G PaciniB Ahrén
Dec 26, 2013·American Journal of Physiology. Endocrinology and Metabolism·Amena ArcherMarion Korach-André
Sep 16, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Kazutoshi YamadaShuichi Kaneko
Jul 3, 2015·Molecular Metabolism·David J PedersenMichael P Czech
Sep 5, 2015·Biology of Sex Differences·Franck Mauvais-Jarvis

❮ Previous
Next ❯

Citations

Apr 16, 2020·European Journal of Clinical Investigation·Stefano MinistriniFederico Carbone
Apr 5, 2020·Metabolites·Christina Savva, Marion Korach-André
Oct 4, 2020·Ecotoxicology and Environmental Safety·Mengcong LiSuquan Song
Feb 2, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Mohammad AlmariAli H Ziyab
May 14, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Patrizia BurraUNKNOWN Special Interest Group Gender in Hepatology of the Italian Association for the Study of the Liver (AISF)
Oct 14, 2021·Journal of Proteome Research·Lucie AumailleyMichel Lebel

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA
transgenic

Software Mentioned

EchoMRI
GraphPad Prism
iAT
R package Rtsne

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Shengli DongSuresh K Alahari
The Journal of Clinical Endocrinology and Metabolism
Kalypso KarastergiouSteven R Smith
© 2022 Meta ULC. All rights reserved