Sex-Specific Management in Patients With Acute Myocardial Infarction and Cardiogenic Shock: A Substudy of the CULPRIT-SHOCK Trial

Circulation. Cardiovascular Interventions
Maria Rubini GimenezHolger Thiele

Abstract

Women are more likely to suffer and die from cardiogenic shock (CS) as the most severe complication of acute myocardial infarction. Data concerning optimal management for women with CS are scarce. Aim of this study was to better define characteristics of women experiencing CS and to the influence of sex on different treatment strategies. In the CULPRIT-SHOCK trial (The Culprit Lesion Only PCI Versus Multivessel PCI in Cardiogenic Shock), patients with CS complicating acute myocardial infarction and multivessel coronary artery disease were randomly assigned to one of the following revascularization strategies: either percutaneous coronary intervention of the culprit-lesion-only or immediate multivessel percutaneous coronary intervention. Primary end point was composite of death from any cause or severe renal failure leading to renal replacement therapy within 30 days. We investigated sex-specific differences in general and according to the revascularization strategies. Among all 686 randomized patients included in the analysis, 24% were women. Women were older and had more often diabetes mellitus and renal insufficiency, whereas they had less often history of previous acute myocardial infarction and smoking. After 30 days, the p...Continue Reading

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Citations

Mar 11, 2020·Circulation. Cardiovascular Interventions·Islam Y ElgendyMamas A Mamas
Sep 30, 2020·Circulation. Heart Failure·Saraschandra VallabhajosyulaGregory W Barsness
Sep 30, 2020·Circulation. Heart Failure·Amanda R Vest, Leslie Cho
Oct 3, 2020·Heart Failure Reviews·N GhionzoliM Cameli
Feb 24, 2021·European Heart Journal. Acute Cardiovascular Care·Jakob JosiassenChristian Hassager
Mar 26, 2021·ESC Heart Failure·Isabell YanDirk Westermann
Jul 2, 2021·World Journal of Cardiology·Syed BukhariIslam Y Elgendy
Aug 24, 2021·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Michal PazdernikBenedikt Schrage

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Software Mentioned

SAS
CULPRIT
SHOCK

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Cardiogenic Shock

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