Sex-specific meiotic drive and selection at an imprinted locus

Genetics
Francisco Ubeda, D Haig

Abstract

We present a one-locus model that breaks two symmetries of Mendelian genetics. Whereas symmetry of transmission is breached by allowing sex-specific segregation distortion, symmetry of expression is breached by allowing genomic imprinting. Simple conditions for the existence of at least one polymorphic stable equilibrium are provided. In general, population mean fitness is not maximized at polymorphic equilibria. However, mean fitness at a polymorphic equilibrium with segregation distortion may be higher than mean fitness at the corresponding equilibrium with Mendelian segregation if one (or both) of the heterozygote classes has higher fitness than both homozygote classes. In this case, mean fitness is maximized by complete, but opposite, drive in the two sexes. We undertook an extensive numerical analysis of the parameter space, finding, for the first time in this class of models, parameter sets yielding two stable polymorphic equilibria. Multiple equilibria exist both with and without genomic imprinting, although they occurred in a greater proportion of parameter sets with genomic imprinting.

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Citations

Aug 12, 2008·Genetica·Hamish G Spencer
Sep 13, 2013·Proceedings. Biological Sciences·Manus M PattenDavid Haig
Apr 15, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David Haig, Amity Wilczek
May 25, 2005·Genetics·Francisco Ubeda, David Haig
Dec 4, 2008·Advances in Pediatrics·John M OpitzLucia Santoro
Jul 4, 2009·Evolution; International Journal of Organic Evolution·Manus M Patten, David Haig
Feb 11, 2015·Evolution; International Journal of Organic Evolution·Yaniv Brandvain, Graham Coop
Sep 5, 2006·Current Biology : CB·Tracey Chapman
Dec 20, 2016·Evolution; International Journal of Organic Evolution·Gonçalo S FariaAndy Gardner
Jul 22, 2006·Biochemical Society Transactions·F Ubeda
Nov 1, 2018·Molecular Biology and Evolution·Xiaoheng Cheng, Michael DeGiorgio
Nov 8, 2017·Nature Ecology & Evolution·Andy Gardner, Francisco Úbeda
Feb 23, 2019·Scientific Reports·Viggo JønssonGeir E Tjønnfjord

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