Sex-specific methylation in Drosophila: an investigation of the Sophophora subgenus.

Genetica
Marícia Fantinel D'AvilaVera Lúcia da Silva Valente

Abstract

Epigenetic phenomena have been widely characterized in the genomes of vertebrates and DNA methylation is a key mechanism of epigenetic regulation. The DNA methylation systems of invertebrates and vertebrates show several notable differences. However, the evolutionary implications of those differences only recently began to be revealed. Our study investigated the recurrence of sex-specific methylation, as previously described for the species Drosophila willistoni, in other species of the Sophophora subgenus that present close evolutionary relationship. The MSRE and Southern blot techniques were used to analyze rDNA of some species of the willistoni, melanogaster, saltans and obscura groups of Drosophila and the results suggested that differential DNA methylation between sexes only occurs in Drosophila tropicalis and D. insularis, two sibling species of the willistoni subgroup. However, only using the MSRE technique we could detect sex-specific patterns of DNA methylation in all species of willistoni subgroup. These results indicate that DNA methylation may present important differences, even between closely related species, shedding new light on this Neotropical species complex.

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Citations

Nov 5, 2011·Yi chuan = Hereditas·Xin-Xin GuoMin Zhang
Aug 1, 2015·Genome Biology and Evolution·Martijn F L DerksHendrik-Jan Megens
Jun 3, 2017·PloS One·Gilberto Cavalheiro VieiraVera Lúcia da Silva Valente
Jul 23, 2019·Archives of Insect Biochemistry and Physiology·Wei ChenMinsheng You
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Jan 18, 2018·Biological Reviews of the Cambridge Philosophical Society·Tanya M PennellJeremy Field
Apr 19, 2018·Genetics and Molecular Biology·Gilberto Cavalheiro VieiraVera Lúcia da Silva Valente

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